ATLANTIC DIP: The Impact of Obesity on Pregnancy Outcome in Glucose-Tolerant Women
- Lisa A. Owens, MD1,
- Eoin P. O'Sullivan, MD1,
- Breeda Kirwan, RN1,
- Gloria Avalos, MSC1,
- Geraldine Gaffney, MD, RCOG2,
- Fidelma Dunne, MD, PHD1 and
- for the ATLANTIC DIP Collaborators
- 1Department of Medicine, National University of Ireland, Galway, Ireland;
- 2Department of Obstetrics and Gynecology, National University of Ireland, Galway, Ireland.
- Corresponding author: Fidelma Dunne, fidelma.dunne{at}nuigalway.ie.
Abstract
OBJECTIVE A prospective study of the impact of obesity on pregnancy outcome in glucose-tolerant women.
RESEARCH DESIGN AND METHODS The Irish Atlantic Diabetes in Pregnancy network advocates universal screening for gestational diabetes. Women with normoglycemia and a recorded booking BMI were included. Maternal and infant outcomes correlated with booking BMI are reported.
RESULTS A total of 2,329 women fulfilled the criteria. Caesarean deliveries increased in overweight (OW) (odds ratio 1.57 [95% CI 1.24–1.98]) and obese (OB) (2.65 [2.03–3.46]) women. Hypertensive disorders increased in OW (2.30 [1.55–3.40]) and OB (3.29 [2.14–5.05]) women. Reported miscarriages increased in OB (1.4 [1.11–1.77]) women. Mean birth weight was 3.46 kg in normal BMI (NBMI), 3.54 kg in OW, and 3.62 kg in OB (P < 0.01) mothers. Macrosomia occurred in 15.5, 21.4, and 27.8% of babies of NBMI, OW, and OB mothers, respectively (P < 0.01). Shoulder dystocia occur in 4% (>4 kg) compared with 0.2% (<4 kg) babies (P < 0.01). Congenital malformation risk increased for OB (2.47 [1.09–5.60]) women.
CONCLUSIONS OW and OB glucose-tolerant women have greater adverse pregnancy outcomes.
Footnotes
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The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
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- Received May 19, 2009.
- Accepted November 19, 2009.
- © 2010 by the American Diabetes Association.
