Serum Vitamin D Concentration Does Not Predict Insulin Action or Secretion in European Subjects With the Metabolic Syndrome
- Hanne L. Gulseth, MD1,2,
- Ingrid M.F. Gjelstad, MSC1,2,
- Audrey C. Tierney, PHD3,
- Julie A. Lovegrove, PHD4,5,
- Catherine Defoort, PHD6,
- Ellen E. Blaak, PHD7,
- Jose Lopez-Miranda, MD, PHD8,
- Beata Kiec-Wilk, MD9,
- Ulférus Ris, MD, PHD10,
- Helen M. Roche, PHD3,
- Christian A. Drevon, MD, PHD2 and
- Kåre I. Birkeland, MD, PHD1
- 1Department of Clinical Endocrinology, Oslo University Hospital Aker and Faculty of Medicine, University of Oslo, Oslo, Norway;
- 2Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Olso, Norway;
- 3Nutrigenomics Research Group, UCD Conway Institute, University College Dublin, Dublin, Republic of Ireland;
- 4Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, U.K.;
- 5Institute of Cardiovascular and Metabolic Research, University of Reading, Reading, U.K.;
- 6Institut National de la Santé et de la Recherche Médicale (INSERM) 476, Human Nutrition and Lipids, University Méditerranée Aix-Marseille 2, Marseille, France;
- 7Department of Human Biology, School for Nutrition, Toxicology and Metabolism (NUTRIM), Maastricht University, Maastricht, the Netherlands;
- 8Lipids and Atherosclerosis Research Unit, Reina Sofía University Hospital, Maimonides Institute for Biomedical Research at Cordoba (IMIBIC), University of Cordoba, Ciber Phyisiopatology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III, Cordoba, Spain;
- 9Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland;
- 10Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
- Corresponding author: Hanne L. Gulseth, h.l.gulseth{at}medisin.uio.no.
Abstract
OBJECTIVE To investigate the relation between serum concentration of 25-hydroxyvitamin D [25(OH)D] and insulin action and secretion.
RESEARCH DESIGN AND METHODS In a cross-sectional study of 446 Pan-European subjects with the metabolic syndrome, insulin action and secretion were assessed by homeostasis model assessment (HOMA) indexes and intravenous glucose tolerance test to calculate acute insulin response, insulin sensitivity, and disposition index. Serum 25(OH)D was measured by high-performance liquid chromatography/mass spectrometry.
RESULTS The 25(OH)D3 concentration was 57.1 ± 26.0 nmol/l (mean ± SD), and only 20% of the subjects had 25(OH)D3 levels ≥75 nmol/l. In multiple linear analyses, 25(OH)D3 concentrations were not associated with parameters of insulin action or secretion after adjustment for BMI and other covariates.
CONCLUSIONS In a large sample of subjects with the metabolic syndrome, serum concentrations of 25(OH)D3 did not predict insulin action or secretion. Clear evidence that D vitamin status directly influences insulin secretion or action is still lacking.
Footnotes
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- Received September 30, 2009.
- Accepted December 30, 2009.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
- © 2010 by the American Diabetes Association.
