Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Hyperglycemia in an Adult Italian Population-Based Cohort

  1. Maurizio Cassader, PHD1
  1. 1Department of Internal Medicine, University of Turin, Torino, Italy;
  2. 2Diabetic Clinic, Hospital of Asti, Asti, Italy;
  3. 3Gradenigo Hospital, Turin, Italy.
  1. Corresponding author: Roberto Gambino, roberto.gambino{at}unito.it.

Abstract

OBJECTIVE To assess whether TCF7L2 polymorphism has a role in the deterioration of glycemic control.

RESEARCH DESIGN AND METHODS Metabolic variables were evaluated at baseline and after 6-year follow-up in 1,480 Caucasian subjects from a population-based cohort.

RESULTS At baseline, T-allele carriers showed significantly lower BMI and homeostasis model assessment for β-cell function (HOMA-B) values and higher fasting glycemia and diabetes prevalence. At follow-up, fasting glucose and HOMA-B index were increased and reduced, respectively, in carriers of the T-allele. Incident impaired fasting glucose (IFG) and incident diabetes were 5.7, 10.7, 16.9% and 1.6, 1.7, 3.0% in the CC, CT, and TT genotypes, respectively. In a multiple logistic regression model, the association between incident IFG and the T-allele was significant (odds ratio [OR] 2.08 [95% CI 1.35–3.20] and 3.56 [2.11–5.98] in CT and TT genotypes, respectively).

CONCLUSIONS The T-allele of TCF7L2 rs7903146 polymorphism was independently associated with increasing fasting glucose values toward hyperglycemia in the follow-up.

Footnotes

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  • Received September 10, 2009.
  • Accepted March 4, 2010.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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  1. Diabetes Care vol. 33 no. 6 1233-1235
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