Prevention of Gestational Diabetes
Feasibility issues for an exercise intervention in obese pregnant women
- Leonie K. Callaway, FRACP, PHD1,2,
- Paul B. Colditz, FRACP, FRCPCH, PHD3,4,
- Nuala M. Byrne, PHD5,6,
- Barbara E. Lingwood, MSC, PHD3,4,
- Ingrid J. Rowlands, PHD7,
- Katie Foxcroft, RN8,
- H. David McIntyre, FRACP9 and
- for the BAMBINO Group*
- 1Royal Brisbane Clinical School, Royal Brisbane and Women's Hospital, Brisbane, Australia;
- 2School of Medicine, The University of Queensland, Brisbane, Australia;
- 3Perinatal Research Centre, The University of Queensland, Brisbane, Australia;
- 4University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital, Brisbane, Australia;
- 5School of Human Movement Studies, Queensland University of Technology, Brisbane, Australia;
- 6Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia;
- 7School of Medicine, The University of Queensland, Brisbane, Australia;
- 8Department of Internal Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia;
- 9Mater Clinical School, School of Medicine, The University of Queensland, Brisbane, Australia.
- Corresponding author: Leonie K. Callaway, .
OBJECTIVE To examine the feasibility of an individualized exercise program to prevent gestational diabetes mellitus (GDM) in obese pregnant women.
RESEARCH DESIGN AND METHODS The study was a pilot randomized controlled trial with obese pregnant women (intervention group, individualized exercise program [n = 25]; control group, usual care [n = 25]). Average weekly energy expenditure (MET hours per week and kilocalories per week) of exercise-specific activity was assessed during pregnancy using the Pregnancy Physical Activity Questionnaire. Fasting glucose and insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed at baseline and 20, 28, and 36 weeks' gestation.
RESULTS Of the women in the intervention group, 16 of 22 (73%) achieved more than 900 kcal/week of exercise-based activity at 28 weeks compared with 8 of 19 women in the control group (42%), P = 0.047. However, insulin resistance (HOMA-IR) did not differ between the groups.
CONCLUSION This intervention was feasible and prompted a modest increase in physical activity. However, we are not confident that this intervention would be sufficient to prevent GDM.
↵*The complete BAMBINO Group: Leonie K. Callaway, Paul B. Colditz, Nuala M. Byrne, Barbare E. Lingwood, Ingrid J. Rowlands, Ainsley Groves, Xanthe Sansome, Briony R. O'Connor, Susan Croaker, Katie Foxcroft, and H. David McIntyre.
Clinical trial reg. no. ACTRN012606000271505, anzctr.org.au.
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- Received December 21, 2009.
- Accepted March 22, 2010.
- © 2010 by the American Diabetes Association.
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