Partial Sleep Restriction Decreases Insulin Sensitivity in Type 1 Diabetes

Table 1

The effects of a night of normal sleep duration versus a night of sleep duration restricted to 4 h on sleep parameters assessed by PSG, basal and insulin-stimulated glucose, and fatty acid metabolism in seven patients with type 1 diabetes

Normal sleep Partial sleep deprivation P
Sleep parameters
    TST (min) 469 ± 8.5 222 ± 7.1 0.02
    Stage 1 (% of TST) 10.6 ± 1.0 10.2 ± 2.1 0.49
    Stage 2 (% of TST) 44.4 ± 2.8 40.4 ± 2.4 0.13
    Stage 3 (% of TST) 22.7 ± 3.4 35.3 ± 4.4 0.02
    REM sleep (% of TST) 22.2 ± 1.7 13.7 ± 2.3 0.04
    Wake time during sleep (% of total sleep period) 4.2 ± 0.7 5.4 ± 2.3 0.87
Basal values
    Glucose (mmol/l) 7.2 ± 1.0 6.7 ± 1.4 0.87
    NEFA (μmol/l) 673 ± 125 591 ± 99 0.35
    EGP (μmol · kg LBM−1 · min−1) 17.6 ± 0.9 16.3 ± 1.0 0.31
Hyperinsulinemic euglycemic clamp study
    Glucose (mmol/l) 5.1 ± 0.2 5.2 ± 0.1 0.23
    Insulin (mU/l) 24.0 ± 2.2 24.9 ± 1.5 0.40
    NEFA (μmol/l) 143 ± 29 133 ± 29 0.69
    EGP (μmol · kg LBM−1 · min−1) 6.2 ± 0.8 6.9 ± 0.6 0.74
    Glucose Rd (μmol · kg LBM−1 · min−1) 25.5 ± 2.6 22.0 ± 2.1 0.04
    Glucose infusion rate (μmol · kg LBM−1 · min−1) 19.0 ± 2.9 14.9 ± 2.1 0.04
  • Data are means ± SEM. Data in bold represent statistical significance. LBM, lean body mass; TST, total sleep time.

This Article

  1. Diabetes Care vol. 33 no. 7 1573-1577