Table 1
The effects of a night of normal sleep duration versus a night of sleep duration restricted to 4 h on sleep parameters assessed by PSG, basal and insulin-stimulated glucose, and fatty acid metabolism in seven patients with type 1 diabetes
| Normal sleep | Partial sleep deprivation | P | |
|---|---|---|---|
| Sleep parameters | |||
| TST (min) | 469 ± 8.5 | 222 ± 7.1 | 0.02 |
| Stage 1 (% of TST) | 10.6 ± 1.0 | 10.2 ± 2.1 | 0.49 |
| Stage 2 (% of TST) | 44.4 ± 2.8 | 40.4 ± 2.4 | 0.13 |
| Stage 3 (% of TST) | 22.7 ± 3.4 | 35.3 ± 4.4 | 0.02 |
| REM sleep (% of TST) | 22.2 ± 1.7 | 13.7 ± 2.3 | 0.04 |
| Wake time during sleep (% of total sleep period) | 4.2 ± 0.7 | 5.4 ± 2.3 | 0.87 |
| Basal values | |||
| Glucose (mmol/l) | 7.2 ± 1.0 | 6.7 ± 1.4 | 0.87 |
| NEFA (μmol/l) | 673 ± 125 | 591 ± 99 | 0.35 |
| EGP (μmol · kg LBM−1 · min−1) | 17.6 ± 0.9 | 16.3 ± 1.0 | 0.31 |
| Hyperinsulinemic euglycemic clamp study | |||
| Glucose (mmol/l) | 5.1 ± 0.2 | 5.2 ± 0.1 | 0.23 |
| Insulin (mU/l) | 24.0 ± 2.2 | 24.9 ± 1.5 | 0.40 |
| NEFA (μmol/l) | 143 ± 29 | 133 ± 29 | 0.69 |
| EGP (μmol · kg LBM−1 · min−1) | 6.2 ± 0.8 | 6.9 ± 0.6 | 0.74 |
| Glucose Rd (μmol · kg LBM−1 · min−1) | 25.5 ± 2.6 | 22.0 ± 2.1 | 0.04 |
| Glucose infusion rate (μmol · kg LBM−1 · min−1) | 19.0 ± 2.9 | 14.9 ± 2.1 | 0.04 |
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Data are means ± SEM. Data in bold represent statistical significance. LBM, lean body mass; TST, total sleep time.
