Dietary Phylloquinone and Menaquinones Intakes and Risk of Type 2 Diabetes
- Joline W.J. Beulens, PHD1,2,
- Daphne L. van der A, PHD3,
- Diederick E. Grobbee, MD1,
- Ivonne Sluijs, MSC1,
- Annemieke M.W. Spijkerman, PHD2 and
- Yvonne T. van der Schouw, PHD1
- 1Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands;
- 2Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, the Netherlands;
- 3Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
- Corresponding author: Joline Beulens, .
OBJECTIVE To investigate whether dietary phylloquinone and menaquinones intakes are related to risk of type 2 diabetes.
RESEARCH DESIGN AND METHODS We used data from a prospective cohort study in 38,094 Dutch men and women, aged 20–70 years. Dietary phylloquinone and menaquinones intakes were assessed using a validated food frequency questionnaire. Diabetes case patients were ascertained mainly via self-report and verified against medical records.
RESULTS During 10.3 years of follow-up, 918 incident cases of diabetes were documented. In a multivariate model adjusting for diabetes risk factors and dietary factors, phylloquinone intake tended to be associated (P = 0.08) with a reduced risk of type 2 diabetes with a hazard ratio (HR) of 0.81 (95% CI 0.66–0.99) for the highest versus the lowest quartile. For menaquinones intake, a linear, inverse association (P = 0.038) with risk of type 2 diabetes was observed with an HR of 0.93 (0.87–1.00) for each 10-μg increment in the multivariate model.
CONCLUSIONS This study shows that both phylloquinone and menaquinones intakes may be associated with a reduced risk of type 2 diabetes.
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- © 2010 by the American Diabetes Association.
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