Increases in Waist Circumference and Weight As Predictors of Type 2 Diabetes in Individuals With Impaired Fasting Glucose: Influence of Baseline BMI

Data from the DESIR study

  1. for the DESIR Study Group6,*
  1. 1Service Endocrinologie, Center Hospitalier Universitaire de Rennes, Université Rennes, Rennes, France, Institut National de la Santé et de la Recherche Médicale (INSERM) U625, Rennes, France;
  2. 2Département d'Endocrinologie, Diabétologie et Nutrition, Assistance Publique-Hôpitaux de Paris, Hôpital Bichat, Université Paris, Diderot, Paris, France, INSERM U695, Paris, France;
  3. 3Service d'Endocrinologie-Diabétologie-Nutrition, Centre Hospitalier Universitaire d'Angers, Université d'Angers, Angers, France;
  4. 4Centre de recherche en Épidémiologie et Santé des Populations, Epidemiology of Diabetes, Obesity, and Chronic Kidney Disease Over the Life Course, INSERM, Villejuif, France;
  5. 5Université Paris-Sud, Villejuif, France;
  6. 6Institut Inter Régional pour la Sante, La Riche, France.
  1. Corresponding author: F. Bonnet, fabrice.bonnet{at}


OBJECTIVE To evaluate in impaired fasting glucose (IFG) the relative importance of increases in waist circumference and weight on progression to type 2 diabetes.

RESEARCH DESIGN AND METHODS The 9-year incidence of diabetes was studied in 979 men and women with baseline IFG, from the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort.

RESULTS Increases in both waist circumference and weight were significantly associated with diabetes incidence. Standardized odds ratios (95% CI) were 1.79 (1.45–2.21) and 1.86 (1.51–2.30), respectively, after controlling for baseline risk factors. The impact of waist circumference increase was greater for BMI <25 kg/m2 (2.40 [1.63–3.52]) than for BMI ≥25 kg/m2 (1.66 [1.28–2.16]) and persisted after adjusting for concurrent changes in either insulinemia or the homeostasis model assessment of insulin resistance index. Weight change had a similar impact in both BMI groups.

CONCLUSIONS In individuals with IFG, it is important to monitor and prevent increases in waist circumference, in particular for those with BMI <25 kg/m2.


  • *Members of the DESIR Study Group can be found in the online appendix at–0368/DC1.

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  • Received February 24, 2010.
  • Accepted May 3, 2010.

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  1. Diabetes Care vol. 33 no. 8 1850-1852
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