Untreated Type 2 Diabetes and Its Complications Are Associated With Subcortical Infarctions
- Rosebud O. Roberts, MBCHB, MS1,
- Kejal Kantarci, MD2,
- Yonas E. Geda, MD, MSC1,3,
- David S. Knopman, MD4,
- Scott A. Przybelski, BS5,
- Stephen D. Weigand, MS5,
- Ronald C. Petersen, PHD, MD1,4 and
- Clifford R. Jack Jr, MD6
- 1Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota;
- 2Division of Vascular/Interventional Radiology, Department of Radiology, Mayo Clinic, Rochester, Minnesota;
- 3Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota;
- 4Department of Neurology, Mayo Clinic, Rochester, Minnesota;
- 5Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota;
- 6Division of Neuroradiology, Department of Radiology, Mayo Clinic, Rochester, Minnesota.
- Corresponding author: Rosebud O. Roberts, .
OBJECTIVE To investigate the association of type 2 diabetes with subcortical infarctions.
RESEARCH DESIGN AND METHODS We investigated this association in subjects with type 2 diabetes (case subjects; n = 93) and without type 2 diabetes (control subjects; n = 186), matched by age, sex, and years of education. Participants were a subset of the Mayo Clinic Study of Aging (median age 79 years) who had undergone magnetic resonance imaging.
RESULTS The frequency of subcortical infarctions was 39% in case subjects and 29% in control subjects (odds ratio 1.59 [95% CI 0.91–2.75]). The association was stronger in case subjects without treatment (2.60 [1.11–6.08]) and in case subjects with diabetes-related complications (1.96 [1.02–3.74]) compared with control subjects.
CONCLUSIONS These findings suggest that untreated type 2 diabetes and type 2 diabetes with complications are associated with subcortical infarctions.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
- Received March 29, 2010.
- Accepted October 19, 2010.
- © 2011 by the American Diabetes Association.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.