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Original Research

Diabetes Antibody Standardization Program

First evaluation of assays for autoantibodies to IA-2β

  1. Michael Schlosser, PHD1,2,
  2. Patricia W. Mueller, PHD3,
  3. Peter Achenbach, MD4,
  4. Vito Lampasona, BSC5,
  5. Polly J. Bingley, MD6⇓ and
  6. Participating Laboratories*
  1. 1Department of Medical Biochemistry and Molecular Biology, Research Group of Predictive Diagnostics, University of Greifswald, Karlsburg, Germany
  2. 2Institute of Pathophysiology, Research Group of Predictive Diagnostics, University of Greifswald, Karlsburg, Germany
  3. 3National Diabetes Laboratory, Centers for Disease Control and Prevention, Atlanta, Georgia
  4. 4Institute of Diabetes Research, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
  5. 5Genomics Unit for the Diagnosis of Human Pathologies, Center for Translational Genomics and Bioinformatics, San Raffaele Scientific Institute, Milan, Italy
  6. 6Diabetes and Metabolism, School of Clinical Sciences, University of Bristol, Bristol, U.K.
  1. Corresponding author: Polly J. Bingley, polly.bingley{at}bristol.ac.uk.
Diabetes Care 2011 Nov; 34(11): 2410-2412. https://doi.org/10.2337/dc11-1161
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Article Figures & Tables

Tables

  • Table 1

    Results for IA-2β autoantibody assays

    Laboratory no.Laboratory-assigned sensitivity (%)Laboratory-assigned specificity (%)AUC95% CIP valueAS 95 (%)Results reportedIA-2β clone
    109NDND0.770.69–0.87<0.000163local unitsMilan
    11539980.720.62–0.82<0.000153cpmMilan
    11647990.700.60–0.80<0.000153local unitsMilan
    118NDND0.680.57–0.79<0.000153cpmMilan
    12053960.730.63–0.82<0.000155local unitsMilan
    12147990.690.58–0.79<0.000149local unitsMilan
    12651980.670.55–0.780.00149local unitsSeattle
    13243990.740.65–0.83<0.000147local unitsMilan
    13347990.690.59–0.80<0.000153local unitsDenver
    15053940.750.66–0.84<0.000153cpmMilan
    15350980.740.65–0.84<0.000152local unitsMilan
    21347920.710.61–0.81<0.000147local unitsMilan
    50437920.650.55–0.750.00420local unitsMilan
    • ND, not designated.

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Diabetes Care: 41 (5)

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May 2018
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Diabetes Antibody Standardization Program
Michael Schlosser, Patricia W. Mueller, Peter Achenbach, Vito Lampasona, Polly J. Bingley, Participating Laboratories
Diabetes Care Nov 2011, 34 (11) 2410-2412; DOI: 10.2337/dc11-1161

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Diabetes Antibody Standardization Program
Michael Schlosser, Patricia W. Mueller, Peter Achenbach, Vito Lampasona, Polly J. Bingley, Participating Laboratories
Diabetes Care Nov 2011, 34 (11) 2410-2412; DOI: 10.2337/dc11-1161
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