Heart Rate Recovery After Exercise Is a Predictor of Silent Myocardial Ischemia in Patients With Type 2 Diabetes
- Tomohide Yamada, MD,
- Takashi Yoshitama, MD, PHD,
- Kunihiko Makino, MD, PHD,
- Tetsuo Lee, MD and
- Fumihiko Saeki, MD, PHD
- Corresponding author: Tomohide Yamada, .
OBJECTIVE Slow heart rate recovery (HRR) predicts all-cause mortality. This study investigated the relationship between silent myocardial ischemia (SMI) and HRR in type 2 diabetes.
RESEARCH DESIGN AND METHODS The study enrolled 87 consecutive patients with type 2 diabetes and no chest symptoms. They underwent treadmill exercise testing and single-photon emission computed tomography imaging with thallium scintigraphy. Patients with abnormal myocardial perfusion images also underwent coronary angiography.
RESULTS SMI was diagnosed in 41 patients (47%). The SMI group showed slower HRR than the non–SMI group (18 ± 6 vs. 30 ± 12 bpm; P < 0.0001). HRR was significantly associated with SMI (odds ratio 0.83 [95% CI 0.75–0.92]; P = 0.0006), even after adjustment for maximal exercise workload, resting heart rate, maximum heart rate, rate pressure product, HbA1c, use of sulfonamides, and a history of cardiovascular disease.
CONCLUSIONS HRR can predict SMI in patients with type 2 diabetes.
- Received July 23, 2010.
- Accepted December 8, 2010.
- © 2011 by the American Diabetes Association.
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