The Charcot Foot in Diabetes

  1. Luigi Uccioli, MD15
  1. From the 1Amputation Prevention Center at Valley Presbyterian Hospital, Los Angeles, California; the
  2. 2Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona; the
  3. 3Southern Arizona Limb Salvage Alliance (SALSA), University of Arizona College of Medicine, Tucson, Arizona; the
  4. 4Department of Medicine, University of Manchester, Manchester, U.K.; the
  5. 5Diabetic Foot Clinic, King's College Hospital, London, U.K.; the
  6. 6Diabetes and Metabolic Diseases Department, Pitié-Salpêtrière University Hospital, Paris, France; the
  7. 7Department of Diabetes and Endocrinology, Nottingham University Hospitals NHS Trust, Nottingham, U.K.; the
  8. 8Institute for Clinical and Experimental Medicine, Diabetes Centre, Prague, Czech Republic; the
  9. 9Department of Diabetes and Angiology, Marienkrankenhaus, Soest, Germany; the
  10. 10Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania; the
  11. 11Department of Orthopedic Surgery, Loyola University Health System, Maywood, Illinois; the
  12. 12Diabetes Center and Foot Care Unit A, Gemelli Hospital, Catholic University, Rome, Italy; the
  13. 13Podiatry Service, Veterans Affairs Medical Center, Lebanon, Pennsylvania; the
  14. 14Department of Orthopedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and the
  15. 15Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
  1. Corresponding author: Lee C. Rogers,{at}


The diabetic Charcot foot syndrome is a serious and potentially limb-threatening lower-extremity complication of diabetes. First described in 1883, this enigmatic condition continues to challenge even the most experienced practitioners. Now considered an inflammatory syndrome, the diabetic Charcot foot is characterized by varying degrees of bone and joint disorganization secondary to underlying neuropathy, trauma, and perturbations of bone metabolism. An international task force of experts was convened by the American Diabetes Association and the American Podiatric Medical Association in January 2011 to summarize available evidence on the pathophysiology, natural history, presentations, and treatment recommendations for this entity.

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