Combination of the Framingham Risk Score and Carotid Intima-Media Thickness Improves the Prediction of Cardiovascular Events in Patients With Type 2 Diabetes
- Michiko Yoshida, MD1,
- Tomoya Mita, MD1,2⇓,
- Risako Yamamoto, PHD1,
- Tomoaki Shimizu, MD1,
- Fuki Ikeda, MD1,
- Chie Ohmura, MD1,
- Akio Kanazawa, MD1,
- Takahisa Hirose, MD1,3,
- Ryuzo Kawamori, MD4 and
- Hirotaka Watada, MD1,2,3,4,5
- 1Department of Medicine, Metabolism, and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- 2Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan
- 3Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan
- 4Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
- 5Center for Beta Cell Biology and Regeneration, Juntendo University Graduate School of Medicine, Tokyo, Japan
- Corresponding author: Tomoya Mita, .
OBJECTIVE The aim of this study was to investigate whether carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) add value to the Framingham risk score (FRS) in predicting the development of cardiovascular diseases (CVDs) in type 2 diabetic patients with a negative history of CVD.
RESEARCH DESIGN AND METHODS Type 2 diabetic patients (n = 783) were retrospectively recruited and followed for CVD.
RESULTS During a 5.4-year follow-up period, 85 incidences of CVD were recorded (10.9%). After adjustment for conventional arterial risk factors, multivariate analysis with the Cox proportional hazards model identified IMT, but not baPWV, as a significant determinant of CVD. In addition, the combination of FRS with IMT, but not with baPWV, improved the prediction of CVD.
CONCLUSIONS Carotid IMT is a significant predictor of CVD in asymptomatic type 2 diabetic patients, and the combination of FRS and IMT improves the prediction of CVD in these patients.
- Received July 15, 2011.
- Accepted September 23, 2011.
- © 2012 by the American Diabetes Association.
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