Combination of the Framingham Risk Score and Carotid Intima-Media Thickness Improves the Prediction of Cardiovascular Events in Patients With Type 2 Diabetes

  1. Hirotaka Watada, MD1,2,3,4,5
  1. 1Department of Medicine, Metabolism, and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan
  2. 2Center for Molecular Diabetology, Juntendo University Graduate School of Medicine, Tokyo, Japan
  3. 3Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan
  4. 4Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan
  5. 5Center for Beta Cell Biology and Regeneration, Juntendo University Graduate School of Medicine, Tokyo, Japan
  1. Corresponding author: Tomoya Mita, tom-m{at}juntedo.ac.jp.

Abstract

OBJECTIVE The aim of this study was to investigate whether carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) add value to the Framingham risk score (FRS) in predicting the development of cardiovascular diseases (CVDs) in type 2 diabetic patients with a negative history of CVD.

RESEARCH DESIGN AND METHODS Type 2 diabetic patients (n = 783) were retrospectively recruited and followed for CVD.

RESULTS During a 5.4-year follow-up period, 85 incidences of CVD were recorded (10.9%). After adjustment for conventional arterial risk factors, multivariate analysis with the Cox proportional hazards model identified IMT, but not baPWV, as a significant determinant of CVD. In addition, the combination of FRS with IMT, but not with baPWV, improved the prediction of CVD.

CONCLUSIONS Carotid IMT is a significant predictor of CVD in asymptomatic type 2 diabetic patients, and the combination of FRS and IMT improves the prediction of CVD in these patients.

  • Received July 15, 2011.
  • Accepted September 23, 2011.

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  1. Diabetes Care vol. 35 no. 1 178-180
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