A Population-Based Study of the Risk of Diabetic Retinopathy in Patients With Type 1 Diabetes and Celiac Disease
- Kaziwe Mollazadegan, MD1⇓,
- Maria Kugelberg, MD, PHD2,
- Scott M. Montgomery, PHD1,3,
- David S. Sanders, MB, CHB, FRCP, MD, FACG4,
- Johnny Ludvigsson, MD, PHD5,6 and
- Jonas F. Ludvigsson, MD, PHD1,7
- 1Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
- 2St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden
- 3Clinical Research Centre, Örebro University Hospital, Örebro, Sweden
- 4Gastroenterology and Liver Unit, Royal Hallamshire Hospital and University of Sheffield, Sheffield, U.K.
- 5Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
- 6Pediatric Clinic, Linköping University Hospital, Linköping, Sweden
- 7Department of Pediatrics, Örebro University Hospital, Örebro, Sweden
- Corresponding author: Kaziwe Mollazadegan, .
OBJECTIVE Celiac disease (CD) is associated with type 1 diabetes (T1D). In the current study, we examined whether CD affects the risk of diabetic retinopathy (DRP) in patients with T1D.
RESEARCH DESIGN AND METHODS This was a population-based cohort study. Through the Swedish National Patient Register, we identified 41,566 patients diagnosed with diabetes in 1964–2009 and who were ≤30 years of age at diagnosis. CD was defined as having villous atrophy (Marsh stage 3) according to small intestinal biopsies performed between 1969 and 2008, with biopsy reports obtained from Sweden’s 28 pathology departments. During follow-up, 947 T1D patients had a diagnosis of CD. We used Cox regression analysis with CD as a time-dependent covariate to estimate adjusted hazard ratios (aHRs) for DRP in patients with T1D and CD and compared them with patients with T1D but no CD.
RESULTS Duration of CD correlated with the risk of DRP. When results were stratified by time since CD diagnosis, individuals with T1D and CD were at a lower risk of DRP in the first 5 years after CD diagnosis (aHR 0.57 [95% CI 0.36–0.91]), followed by a neutral risk in years 5 to <10 (1.03 [0.68–1.57]). With longer follow-up, coexisting CD was a risk factor for DRP (10 to <15 years of follow-up, aHR 2.83 [95% CI 1.95–4.11]; ≥15 years of follow-up, 3.01 [1.43–6.32]).
CONCLUSIONS Having a diagnosis of CD for >10 years is a risk factor for the development of DRP in T1D. Long-standing CD in patients with T1D merits intense monitoring of DRP.
This article contains Supplementary Data online at http://care.diabetesjournals.org/lookup/suppl/doi:10.2337/dc12-0766/-/DC1.
- Received April 22, 2012.
- Accepted July 19, 2012.
- © 2013 by the American Diabetes Association.
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