No Difference in Vitamin D Levels Between Children Newly Diagnosed With Type 1 Diabetes and Their Healthy Siblings: A 13-Year Nationwide Danish Study

  1. Jannet Svensson, MD, PHD1
  1. 1Herlev University Hospital, Herlev, Denmark
  2. 2Steno Diabetes Center, Gentofte, Denmark
  3. 3Department of Clinical Biochemistry and Molecular Biology, Hvidovre Hospital, Hvidovre, Denmark
  4. 4Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
  5. 5Hagedorn Research Institute, Gentofte, Denmark
  6. 6Glostrup Research Institute, Glostrup University Hospital, Glostrup, Denmark
  7. 7Department of Biomedical Science, University of Copenhagen, Copenhagen, Denmark
  1. aCorresponding author: Steffen U. Thorsen, s.u.thorsen{at}

The causes of the worldwide increase in type 1 diabetes (T1D) in children are still largely unknown. In Denmark, the increase in incidence is steep at 3.4% annually and does not appear to be leveling out (1). Lower levels of 25-hydroxyvitamin D [25(OH)D] have been found in patients with newly diagnosed T1D compared with healthy control subjects, implying that 25(OH)D might play a role in the pathogenesis of T1D (2,3). We aimed to elucidate the possible association between low levels of 25(OH)D and T1D by measuring 25(OH)D levels in children with newly diagnosed T1D and their healthy siblings in Denmark across a 13-year study period (1997–2009).

We included 1,803 children (907 T1D patients and 896 siblings) in the data analyses. The children were aged 0–18 years (mean …

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