Bariatric Surgery Improves the Metabolic Profile of Morbidly Obese Patients With Type 1 Diabetes
- Stacy A. Brethauer1,
- Ali Aminian1,
- Raul J. Rosenthal2,
- John P. Kirwan3,
- Sangeeta R. Kashyap3 and
- Philip R. Schauer1
- 1Bariatric and Metabolic Institute, Cleveland Clinic, Cleveland, OH
- 2Bariatric and Metabolic Institute, Cleveland Clinic Florida, Weston, FL
- 3Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH
- Corresponding author: Stacy A. Brethauer, .
A growing body of evidence has demonstrated significant and sustained improvement in glycemic control in type 2 diabetes after bariatric surgery. However, there are limited data on the impact of bariatric surgery in type 1 diabetes (T1D). Only fewer than 10 cases of bariatric surgery in patients with T1D have been reported in the literature, which show a significant weight reduction and improvement in glycemic control (1–3). A recent experimental study in a rat model of spontaneous development of T1D has also shown that a particular type of gastrointestinal bypass (duodenal-jejunal bypass surgery) lowers blood glucose concentration within 2 days after surgery (4). The aim of this study was to assess the metabolic outcomes, including the glycemic status, of patients with T1D after bariatric surgery.
Clinical outcomes and metabolic parameters of 10 morbidly obese patients with poorly controlled T1D who underwent laparoscopic bariatric surgery between 5 January 2005 and 12 …