Original Articles

• • Ronald E Chance,
  • Franz H Enzmann,
  • John A Galloway,
  • Alan Glynne,
  • and John H Marsden

  Introduction

  Diabetes Care March/April 1981 4:139; doi:10.2337/diacare.4.2.139
• • Jay S Skyler,
  • Ernst F Pfeiffer,
  • Sotos Raptis,
  • and Gian Carlo Viberti

  Biosynthetic Human Insulin: Progress and Prospects

  Diabetes Care March/April 1981 4:140-143; doi:10.2337/diacare.4.2.140
• • Pierre De Meyts,
  • Philippe Halban,
  • and K Dieter Hepp

  In Vitro Studies on Biosynthetic Human Insulin: an Overview

  Diabetes Care March/April 1981 4:144-146; doi:10.2337/diacare.4.2.144
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  • Ronald E Chance,
  • Eugene P Kroeff,
  • James A Hoffmann,
  • and Bruce H Frank

  Chemical, Physical, and Biologic Properties of Biosynthetic Human Insulin

  Diabetes Care March/April 1981 4:147-154; doi:10.2337/diacare.4.2.147
  • Abstract
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  • Sotos Raptis,
  • Constantine Karaiskos,
  • Franz Enzmann,
  • Dimitrios Hatzidakis,
  • Christos Zoupas,
  • Athanasios Souvatzoglou,
  • E Diamantopoulos,
  • and Spyridon Moulopoulos

  Biologic Activities of Biosynthetic Human Insulin in Healthy Volunteers and Insulin-dependent Diabetic Patients Monitored by the Artificial Endocrine Pancreas

  Diabetes Care March/April 1981 4:155-162; doi:10.2337/diacare.4.2.155
  • Abstract
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  • M Massi-Benedetti,
  • J M Burrin,
  • B Capaldo,
  • and K G M M Alberti

  A Comparative Study of the Activity of Biosynthetic Human Insulin and Pork Insulin Using the Glucose Clamp Technique in Normal Subjects

  Diabetes Care March/April 1981 4:163-167; doi:10.2337/diacare.4.2.163
  • Abstract
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  • P Bottermann,
  • H Gyaram,
  • K Wahl,
  • R Ermler,
  • and A Lebender

  Pharmacokinetics of Biosynthetic Human Insulin and Characteristics of Its Effect

  Diabetes Care March/April 1981 4:168-169; doi:10.2337/diacare.4.2.168
  • Abstract
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  • Konrad Federlin,
  • Heinrich Laube,
  • and Hans Georg Velcovsky

  Biologic and Immunologic in Vivo and In Vitro Studies with Biosynthetic Human Insulin

  Diabetes Care March/April 1981 4:170-174; doi:10.2337/diacare.4.2.170
  • Abstract
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  • G C Viberti,
  • J C Pickup,
  • H Keen,
  • R W Bilous,
  • M Mattock,
  • R J Jarrett,
  • A Glynne,
  • and R Rogers

  Biosynthetic Human Insulin: Effect in Healthy Men on Plasma Glucose and Non-Esterified Fatty Acids in Comparison with Highly Purified Pork Insulin

  Diabetes Care March/April 1981 4:175-179; doi:10.2337/diacare.4.2.175
  • Abstract
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  • Kurt Weinges,
  • Manfred Ehrhardt,
  • and Franz Enzmann

  Comparison of Biosynthetic Human Insulin and Pork Insulin in the Gerritzen Test

  Diabetes Care March/April 1981 4:180-182; doi:10.2337/diacare.4.2.180
  • Abstract
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  • John A Galloway,
  • C T Spradlin,
  • M A Root,
  • and S E Fineberg

  The Plasma Glucose Response of Normal Fasting Subjects to Neutral Regular and NPH Biosynthetic Human and Purified Pork Insulins

  Diabetes Care March/April 1981 4:183-188; doi:10.2337/diacare.4.2.183
  • Abstract
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  • J Beyer,
  • Th Weber,
  • G Schulz,
  • W Hassinger,
  • A Westerburg,
  • and U Cordes

  Comparison of Biosynthetic Human Insulin and Pork Insulin During Rest, Food Ingestion, and Physical Work in Insulin-dependent Diabetic Subjects Using a Glucose Controlled Insulin Infusion System

  Diabetes Care March/April 1981 4:189-192; doi:10.2337/diacare.4.2.189
  • Abstract
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  • M Klier,
  • W Kerner,
  • A A Torres,
  • and E F Pfeiffer

  Comparison of the Biologic Activity of Biosynthetic Human Insulin and Natural Pork Insulin in Juvenile-onset Diabetic Subjects Assessed by the Glucose Controlled Insulin Infusion System

  Diabetes Care March/April 1981 4:193-195; doi:10.2337/diacare.4.2.193
  • Abstract
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  • G Schernthaner,
  • H Ludwig,
  • R Jarisch,
  • and H Bruneder

  Immediate-Type Allergy Against Insulin Itself: Clinical and Immunologic Studies on a Diabetic Patient with Insulin Intolerance

  Diabetes Care March/April 1981 4:196-201; doi:10.2337/diacare.4.2.196
  • Abstract
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  • W Beischer,
  • V Maier,
  • E M Jonatha,
  • D Hartweg,
  • and G Kratzsch

  Immunologic Properties of Biosynthetic Human Insulin in Vitro

  Diabetes Care March/April 1981 4:202-204; doi:10.2337/diacare.4.2.202
  • Abstract
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  • Werner K Waldhäusl,
  • Gerhard Kastner,
  • Martin Komjati,
  • and Paul Bratusch-Marrain

  Studies on the Biologic Actions of Biosynthetic Human Insulin In Vitro and in Diabetic Man

  Diabetes Care March/April 1981 4:205-208; doi:10.2337/diacare.4.2.205
  • Abstract
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  • Linda M Keefer,
  • Marie AgnÈs Piron,
  • and Pierre De Meyts

  Receptor Binding Properties and Biologic Activity In Vitro of Biosynthetic Human Insulin

  Diabetes Care March/April 1981 4:209-214; doi:10.2337/diacare.4.2.209
  • Abstract
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  • Werner Bachmann,
  • Caspar Sieger,
  • Florian Lacher,
  • and Norbert Lotz

  Binding of Biosynthetic Human Insulin to Erythrocytes of Normal and Insulin-dependent Diabetic Subjects: Comparison with Pork and Human Pancreatic Insulin

  Diabetes Care March/April 1981 4:215-219; doi:10.2337/diacare.4.2.215
  • Abstract
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  • Jean Louis Carpentier,
  • Philippe A Halban,
  • Albert E Renold,
  • and Lelio Orci

  Internalization of ¹²⁵I-Insulin by IM-9 Cultured Human Lymphocytes: A Comparison Between A14-Monoiodo-Pork and Biosynthetic Human Insulin

  Diabetes Care March/April 1981 4:220-222; doi:10.2337/diacare.4.2.220
  • Abstract
• • Max Fehlmann,
  • Yannick Le Marchand-Brustel,
  • Jacqueline Dolais-Kitabgl,
  • Odette Morin,
  • and Pierre Freychet

  Biologic Activity and Receptor Binding Properties of Biosynthetic Human Insulin in Isolated Rat Hepatocytes and Mouse Soleus Muscle In Vitro

  Diabetes Care March/April 1981 4:223-227; doi:10.2337/diacare.4.2.223
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  • R D Fussgaenger,
  • H H Ditschuneit,
  • H Martini,
  • H Wiebauer-De Lenardis,
  • H Etzrodt,
  • Ch Thun,
  • H Ditschuneit,
  • E F Pfeiffer,
  • and F Enzmann

  Potency of Biosynthetic Human Insulin Determined In Vitro

  Diabetes Care March/April 1981 4:228-234; doi:10.2337/diacare.4.2.228
  • Abstract
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  • Steen Gammeltoft

  Receptor Binding of Biosynthetic Human Insulin on Isolated Pig Hepatocytes

  Diabetes Care March/April 1981 4:235-237; doi:10.2337/diacare.4.2.235
  • Abstract
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  • Philippe A Halban,
  • Michael Berger,
  • Asllan Gjinovci,
  • and Albert E Renold

  Biologic Activity and Pharmacokinetics of Biosynthetic Human Insulin in the Rat

  Diabetes Care March/April 1981 4:238-243; doi:10.2337/diacare.4.2.238
  • Abstract
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  • Jerrold M Olefsky

  Insulin Binding, Biologic Activity, and Metabolism of Biosynthetic Human Insulin

  Diabetes Care March/April 1981 4:244-247; doi:10.2337/diacare.4.2.244
  • Abstract
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  • KG Petersen,
  • K Schlüter,
  • S Steinhilber,
  • and L Kerp

  Binding of Biosynthetic Human Insulin to Human Antibodies and Receptors

  Diabetes Care March/April 1981 4:248-249; doi:10.2337/diacare.4.2.248
  • Abstract
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  • Ole Sonne,
  • James E Foley,
  • and Jørgen Gliemann

  The Biologic Potency and Binding Affinity of Biosynthetic Human Insulin in Isolated Rat Adipocytes

  Diabetes Care March/April 1981 4:250-251; doi:10.2337/diacare.4.2.250
  • Abstract
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  • E J Verspohl and
  • H P T Ammon

  Binding of Insulin to Rat Pancreatic Islets: Comparison Between Pancreatic Human Insulin and Biosynthetic Human Insulin

  Diabetes Care March/April 1981 4:252-253; doi:10.2337/diacare.4.2.252
  • Abstract
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  • Tj Wieringa,
  • J P M Van Putten,
  • M Van Dijk-Besling,
  • and H M J Krans

  Receptor Binding and Effect of Biosynthetic Human Insulin on 2-Deoxyglucose Transport

  Diabetes Care March/April 1981 4:254-256; doi:10.2337/diacare.4.2.254
  • Abstract
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  • J Zapf and
  • E R Froesch

  Comparison of Pancreatic Human and Biosynthetic Human Insulin with Respect to Their Action on Adipocytes and Chick Embryo Fibroblasts

  Diabetes Care March/April 1981 4:257-259; doi:10.2337/diacare.4.2.257
  • Abstract
• • John A Galloway and
  • John H Marsden

  Clinical Trials with Biosynthetic Human Insulin

  Diabetes Care March/April 1981 4:260-261; doi:10.2337/diacare.4.2.260
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  • John E Gerich

  An Appraisal of the Role of Biosynthetic Human Insulin in the Future Treatment of Diabetes Mellitus

  Diabetes Care March/April 1981 4:262-264; doi:10.2337/diacare.4.2.262
  • Abstract
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  • Donald J Chisholm,
  • Edward W Kraegen,
  • and Guido S Zelenka

  Programming of Insulin Delivery with Meals During Subcutaneous Insulin Infusion

  Diabetes Care March/April 1981 4:265-268; doi:10.2337/diacare.4.2.265
  • Abstract
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  • Jose Barbosa,
  • Lois Menth,
  • John Eaton,
  • David Sutherland,
  • Esther F Freier,
  • and John Najarian

  Long-Term, Ambulatory, Subcutaneous Insulin Infusion versus Multiple Daily Injections in Brittle Diabetic Patients

  Diabetes Care March/April 1981 4:269-274; doi:10.2337/diacare.4.2.269
  • Abstract
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  • Wayne K Davis,
  • Alan L Hull,
  • and Michele L Boutaugh

  Factors Affecting the Educational Diagnosis of Diabetic Patients

  Diabetes Care March/April 1981 4:275-278; doi:10.2337/diacare.4.2.275
  • Abstract
• • Neil J Goldberg,
  • Terence D Wingert,
  • Seymour R Levin,
  • Samuel E Wilson,
  • and John F Viljoen

  Insulin Therapy in the Diabetic Surgical Patient: Metabolic and Hormone Response to Low Dose Insulin Infusion

  Diabetes Care March/April 1981 4:279-284; doi:10.2337/diacare.4.2.279
• Office Guide to Diagnosis and Classification of Diabetes Mellitus and Other Categories of Glucose Intolerance

  Diabetes Care March/April 1981 4:335; doi:10.2337/diacare.4.2.335