Internalization of 125I-Insulin by IM-9 Cultured Human Lymphocytes: A Comparison Between A14-Monoiodo-Pork and Biosynthetic Human Insulin
- Institute of Histology and Embryology, University of Geneva School of Medicine Geneva, Switzerland
- Institute of Clinical Biochemistry, University of Geneva Geneva, Switzerland
- Address reprint requests to J.-L. Carpentier, The Institute of Histology and Embryology, University of Geneva School of Medicine, 1211 Geneva 4, Switzerland.
Abstract
Human insulin synthesized from A- and B-chains separately produced in Escherichia coli from cloned genes was characterized by examining its interaction biochemically and morphologically with IM-9 cultured human lymphocytes. Biosynthetic human insulin (BHI) behaves similarly to pork insulin with respect both to its binding properties and to the rate and magnitude at which it is internalized by the cells.
- Copyright © 1981 by the American Diabetes Association
