Plasma Free Insulin Profiles After Administration of Insulin by Jet and Conventional Syringe Injection
- Address reprint requests to Philip Home, Department of Clinical Biochemistry and Metabolic Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP England.
Abstract
Plasma free insulin profiles in insulin-dependent diabetic subjects were compared after jet and syringe injection of insulin. Jet injection of insulin resulted in a shift of the free insulin profile to the left. Thus higher plasma free insulin levels were found over the first 30 min after injection (P < 0.05), while after 240 min plasma free insulin levels were lower than those seen following syringe injection (P < 0.05). Significant differences in the response of blood glucose and 3-hydroxybutyrate levels reflected the differences in plasma free insulin levels. Jet administration results in more rapid absorption of insulin and could be useful in providing a more physiologic postprandial insulin profile than that seen after conventional injection.
- Copyright © 1981 by the American Diabetes Association
