Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

Effect of ceBMI on type 1 diabetes risk comparing traditional overweight/obese ceBMI definitions to age- and sex-specific ceBMI diabetes risk thresholds. Proportion type 1 diabetes–free pediatric subjects of the PTP cohort according to age (≥12 vs. <12 years old) and sex strata (males vs. females). A, C, E, and G: Assessment of overweight/obese threshold based on the 85th percentile for age- and sex-adjusted BMI. Dotted lines indicate ceBMI ≥0 (overweight/obese); solid gray indicates ceBMI <0 (nonoverweight/obese). B, D, F, and H: Assessment of ceBMI diabetes risk thresholds identified by recursive partitioning. Dotted lines indicate greater than or equal to age- and sex-specific ceBMI diabetes risk threshold; solid gray indicates less than age- and sex-specific ceBMI diabetes risk threshold. All models adjusted for antibody number (single vs. multiple).