Low Incidence of End-Stage Renal Disease in Childhood-Onset Type 1 Diabetes Followed for Up to 42 Years
Article Figures & Tables
Figures
- Figure 1
Incidence rates of ESRD per 1,000 person-years in 7,871 patients with type 1 diabetes who had received a diagnosis before 15 years of age during 1973–1982 and 1989–2012.
- Figure 2
Cumulative incidence of ESRD in 7,871 patients with type 1 diabetes who had received a diagnosis before 15 years of age during 1973–1982 and 1989–2012. A: By sex, P = 0.017. B: By age at diagnosis of diabetes, P = 0.011. C: By time period of diagnosis of diabetes, P = 0.38. P values in A and C were calculated using the log-rank test and in B by the log-rank test, test for trend.
Tables
- Table 1
Demographic characteristics of the study population of childhood-onset (<15 years of age) type 1 diabetes in Norway, followed for ESRD, mortality, and emigration, or until 30 November 2015
Total Male Female Year of diagnosis 1973–1982 1989–2012 Participants 7,871 (100) 4,242 (53.9) 3,629 (46.1) 1,888 (24.0) 5,983 (76.0) Age at diagnosis of type 1 diabetes, years 8.8 (0.6–14.9) 8.8 (0.6–14.9) 8.7 (0.6–14.9) 9.1 (0.6–14.9) 8.7 (0.6–14.9) Duration of diabetes, years 18.8 (0–42.9) 18.7 (0–42.9) 18.8 (0–42.9) 35.8 (0–42.9) 13.4 (0–26.9) Age at end of follow-up, years 27.6 (1.8–57.5) 27.6 (3.7–57.5) 27.5 (1.8–57.0) 44.8 (3.9–57.5) 22.2 (1.8–41.6) Follow-up, person-years 147,714 79,381 68,333 67,411 80,303 Participants in whom ESRD developed 103 (1.3) 67 (1.6) 36 (1.0) 86 (4.6) 17 (0.3) Incidence rates of ESRD per 1,000 person-years (95% CI) 0.69 (0.57–0.85) 0.84 (0.66–1.07) 0.52 (0.38–0.73) 1.28 (1.03–1.58) 0.53 (0.38–0.73) Time from diagnosis of diabetes to ESRD, years 25.9 (12.7–39.1) 26.4 (14.1–39.1) 24.8 (12.7–37.4) 27.2 (16.5–39.1) 18.9 (12.7–24.6) Age at diagnosis of ESRD, years 35.9 (22.1–48.3) 36.5 (24.1–48.3) 34.6 (22.1–45.8) 37.0 (22.1–48.3) 29.9 (22.4–38.7) Dead 285 (3.6) 200 (4.7) 85 (2.3) 204 (10.8) 81 (1.4) Emigrated 108 (1.4) 48 (1.1) 60 (1.7) 26 (1.4) 82 (1.4) Deceased participants who had ESRD 31 (10.9) 22 (11.0) 9 (10.6) 27 (13.2) 4 (4.9) Data are n (%) or mean (range), unless otherwise indicated.
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