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Comparison of Two Indices of Glycemic Control in Diabetic Subjects: Glycosylated Serum Protein and Hemoglobin

  1. Thomas D Mehl,
  2. S E Wenzel,
  3. B Russell,
  4. D Gardner and
  5. T J Merimee
  1. Department of Medicine, Division of Endocrinology, University of Florida Gainesville, Florida 32610
  1. Address reprint requests to Dr. Thomas J. Merimee at the above address.

Abstract

Glycosylated serum protein (GSP) and glycosylated hemoglobin (GHb) were measured in 263 insulindependent and 41 non-insulin-dependent diabetic subjects. Both indices provided useful information in type II diabetes, but were extremely poor in judging control in type I diabetes. In both groups, there was poor correlation of the fasting serum glucose with either GSP or GHb. Only 4% of type I diabetic subjects had normal values for both GSP and GHb. Of subjects with elevated GSP, 98% had elevated GHb; 25% of subjects with elevated GHb values had normal values for GSP.

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