Chlorpropamide-induced Hyponatremia: Incidence and Risk Factors
- Takashi Kadowaki, MD,
- Ryoko Hagura, MD,
- Hiroshi Kajinuma, MD,
- Nobusada Kuzuya, MD and
- Sho Yoshida, MD
- Institute for Adult Diseases, Asahi Life Foundation Tokyo Department of Internal Medicine, Jichi Medical School Tochigi, Japan
- Address reprint requests to Takashi Kadowaki, M.D., The Third Department of Internal Medicine, University of Tokyo, 7–3–1 Hongo, Bunkyo-ku, Tokyo 113, Japan
Abstract
The incidence and risk factors of chlorpropamide-induced hyponatremia were assessed in diabetic outpatients. In 176 chlorpropamide-treated patients, 11 (6.3%) exhibited hyponatremia (serum sodium ≤ 129 meq/L) during the mean follow-up period of 7.4 yr. In contrast, only one (0.6%) developed hyponatremia in 162 tolbutamide or glibenclamide-treated patients (P < 0.005). Moreover, administration to elderly patients and combination with thiazide diuretics were regarded as significantly potent risk factors for the development of hyponatremia in patients receiving chlorpropamide.
- Copyright © 1983 by the American Diabetes Association
