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Nephropathy in Indian Patients with Non-insulin-dependent Diabetes in the Young

  1. I Jialal, M.D.,
  2. M C Rajput, M.R.C.P.,
  3. A C Asmal, M.D. Ph.D. and
  4. S M Joubert, F.R.C.Path.
  1. S.A. Medical Research Council Preclinical Diagnostic Chemistry Research Unit, Department of Chemical Pathology and Medicine, University of Natal Medical School South Africa
  2. Joslin Diabetes Center Boston, Massachusetts

Abstract

In 85 patients diagnosed as having non-insulin-dependent diabetes in the young (NIDDY), 6 were found to have nephropathy. The duration of diabetes ranged from 2 to 17 yr; 5 of the 6 patients had retinopathy as evidenced by fluoroscein angiography (3 with proliferative changes). All 6 patients had a 24-h urinary protein excretion >0.5 g and a glomerular filtration rate <80 ml/min. Serum β2-microglobulin levels were increased in all 6 patients, while only 3 had increased serum creatinine levels.

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