High-viscosity Hydroxypropylmethylcellulose Blunts Postprandial Glucose and Insulin Responses

Abstract

Abstract Objective. High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract. Clinical trials demonstrate that consumption of HV-HPMC significantly lowers cholesterol, but limited information has been available on the influence of HV-HPMC on postprandial insulin and glucose responses. The objective of this investigation was to assess the influence of HV-HPMC on postprandial glucose and insulin responses in overweight and obese men and women.

Abstract Research Design and Methods. Participants were 31, overweight or obese men and women without diabetes who underwent 3 breakfast meal tests in random order, separated by ≥72 hours. Test meals contained 75 g carbohydrate plus 4 g or 8 g HV-HPMC, or control (8 g cellulose), delivered in a double-blind fashion.

Abstract Results. Peak glucose was significantly lower (p < 0.001) after both HV-HPMC-containing meals [7.4 mmol/L (4 g) and 7.4 mmol/L (8 g)] compared to the control meal (8.6 mmol/L). Peak insulin concentrations and the incremental areas for glucose and insulin from 0-120 min were also significantly reduced after both HV-HPMC doses vs. control (all p < 0.01).

Abstract Conclusions. These findings indicate that HV-HPMC consumption reduces postprandial glucose and insulin excursions, which may favorably alter risks for diabetes and cardiovascular disease.

Registry Number: Exempt