Carotid intima-media thickness in pediatric type 1 diabetes patients

doi:10.2337/dc07-0922

Carotid intima-media thickness in pediatric type 1 diabetes patients

Rocio Rabago Rodriguez, MD^a,
Rita A. Gómez-Díaz, MD (ritagomezdiaz{at}netscape.net)^d,
Janet Tanus Haj, MD^c,
Francisco Jose Avelar Garnica, MD^c,
Eleazar Ramirez Soriano, MD^a,
Elisa Nishimura Meguro, MD^a,
Carlos A. Aguilar-Salinas, MD^b and
Niels H. Wacher, MD, PhD^d

^aServicio de Endocrinología. UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico city. México
^bDepartamento de Endocrinología y Metabolismo. Instituto Nacional de Ciencias Médicas y Nutrición. Mexico City. México
^cServicio de Radiodiagnóstico and
^dUnidad de Investigación Médica en Epidemiología Clínica UMAE Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social (IMSS), Mexico City. México

Abstract

Objective: To compare the carotid artery intima-media thickness in type 1 diabetes patients against healthy controls matched for age, gender, height and body mass index.

Research Design and Methods: The evaluation consisted in anthropometric measurements, biochemical parameters and a carotid Doppler and real-time ultrasound (in which the cIMT, the peak systolic velocity (PSV) and the end diastolic velocity (EDV) were measured using standardized procedures.

Results: 52 patients and 47 control subjects were included. No significant differences existed in the characteristics between cases and controls (mean age 11.8± 3.1 vs 11.8± 2.8 years, weight 42.2± 15.3 vs 44.2± 14.4 kg, height 1.45 ± 0.15 vs 1.47± 0.15mts, BMI 19.3± 3.2vs 19.9± 4.4, systolic blood pressure 99.1± 9.9vs 99.6± 9 mmHg and diastolic blood pressure 63± 6.4 vs 62.0± 5.7 mmHg, respectively). The duration of diabetes was 4.8 ±3.2 years (range 6-144 months) The mean HbA1c was 8.6 ±1.6 %. A significantly higher cIMT was found in the patients with type 1 diabetes (0.463± 0.04 mm vs 0.441± 0.04 (p=0.001)). In contrast both PSV 107.1± 22.8 vs 119.3 ± 19.2 (p<0.005) and EDV 28.4± 6.0 vs 33.0± 7.0 (p<0.001) were higher in the control subjects.

Conclusions: Type 1 diabetes is associated with higher cIMT and decreased flow velocities in a pediatric population.