Lifestyle Intervention and Adipokine Levels in Subjects at High Risk for Type 2 Diabetes - The SLIM Study
- E. Corpeleijn, PhD (E.Corpeleijn{at}hb.unimaas.nl)1,
- E.J.M. Feskens, PhD2,,3,
- E.H.J.M. Jansen, PhD4,
- M. Mensink, MD, PhD1,
- W.H.M. Saris, MD, PhD1 and
- E.E. Blaak, PhD1
- 1 Human Biology, Nutrition and Toxicology Research Institute NUTRIM, Maastricht, The Netherlands
- 2 Human Nutrition, Wageningen University and Research Center, Wageningen, The Netherlands
- 3 Centre for Nutrition and Health, National Institute for Public Health and Environment, Bilthoven, The Netherlands
- 4 Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and Environment, Bilthoven, The Netherlands
Abstract
Abstract We investigated whether circulating adipokine concentrations can be altered by lifestyle intervention according to general recommendations in subjects at risk for diabetes as well as the potential of leptin, adiponectin and resistin as biomarkers for lifestyle-induced improvements in glucose metabolism and insulin resistance.
Abstract In the SLIM study, 147 men and women with impaired glucose tolerance (IGT) were randomized to either a combined diet-and-exercise intervention or a control program. At baseline and after one year, an oral glucose tolerance test, an exercise test and anthropometric measurements were performed. After one year, complete data of 103 subjects (50 intervention/53 control) were obtained.
Abstract Lifestyle intervention reduced plasma leptin concentrations (-14.2%) in IGT subjects, but did not alter plasma adiponectin (-0.3%) or resistin (-6.5%) concentrations, despite marked improvements in glucose tolerance and insulin resistance. Changes in leptin concentration were related to improvements in insulin sensitivity independent of changes in body composition.
Footnotes
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- Received March 7, 2007.
- Accepted September 14, 2007.
- Copyright © American Diabetes Association
