The Effect of Cinnamon on Glucose Control and Lipid Parameters
- William L Baker, Pharm.D., BCPS1,,2,
- Gabriela Gutierrez-Williams, Pharm.D.2,
- C. Michael White, Pharm.D., FCP, FCCP1,,2,
- Jeffrey Kluger, MD3 and
- Craig I Coleman, Pharm.D. (ccolema{at}harthosp.org)1,,2
- University of Connecticut1,
- Storrs, CT and Drug Information2
- and Cardiology3 at Hartford Hospital, Hartford, CT
Abstract
Objective – To perform a meta-analysis of randomized controlled trials of cinnamon to better characterize its impact on glucose and plasma lipids.
Research Design & Methods – A systematic literature search through July 2007 was conducted to identify randomized, placebo-controlled trials of cinnamon that reported data on hemoglobin A1c (HbA1c), fasting blood glucose (FBG) or lipid parameters. The mean change in each study endpoint from baseline was treated as a continuous variable and the weighted mean difference was calculated as the difference between the mean value in the treatment and control groups. A random-effects model was used.
Results – Five prospective, randomized controlled trials (n=282) were identified. Upon meta-analysis, the use of cinnamon did not significantly alter HbA1c, FBG, or lipid parameters. Subgroup and sensitivity analyses did not significantly change the results.
Conclusion – Cinnamon does not appear to improve HbA1c, FBG or lipid parameters in patients with type 1 or 2 DM.
Footnotes
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- Received August 29, 2007.
- Accepted September 28, 2007.
- Copyright © American Diabetes Association
