High serum uric acid as a novel risk factor for type 2 diabetes mellitus

  1. Abbas Dehghan, MD, DSc1,
  2. Mandy van Hoek, MD2,
  3. Eric J.G. Sijbrands, MD, PhD2,
  4. Albert Hofman, MD, PhD1 and
  5. Jacqueline C.M. Witteman, PhD (j.witteman{at}erasmusmc.nl)1
  1. 1 Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
  2. 2 Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands

    Abstract

    Objective: To investigate the association between serum uric acid level and risk of type 2 diabetes mellitus.

    Research Design and Methods: The population for analysis consisted of 4536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow up, 462 subjects developed diabetes.

    Results: The age- and sex-adjusted hazard ratios (95% confidence interval) for diabetes were 1.30 (0.96 – 1.76) for the second, 1.63 (1.21 – 2.19) for the third, and 2.83 (2.13 – 3.76) for the fourth quartile of serum uric acid, compared to the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL-cholesterol, the hazard ratios decreased to 1.08 (0.78 – 1.49), 1.12 (0.81 – 1.53), and 1.68 (1.22 – 2.30), respectively.

    Conclusion: The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.

    Footnotes

      • Received July 6, 2007.
      • Accepted October 23, 2007.

    This Article

    1. Published online before print October 31, 2007, doi: 10.2337/dc07-1276
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