Quantifying the Impact of a Short-interval interruption of Insulin-Pump Infusion Sets on Glycemic Excursions

Abstract

Abstract This prospective, open-label study was designed to measure the impact of short-term infusion-set disconnects on glucose levels. Continuous subcutaneous insulin infusion (CSII) therapy allows for uninterrupted delivery of insulin. Patients disconnect their insulin pumps from their infusion sets when showering, swimming, exercising, or during intimate moments. Interrupting insulin infusion results in cessation of the basal insulin delivery. Nineteen subjects with T1DM were studied on 2 separate in-clinic days. One hour after arriving at the clinic in a fasting state, subjects either temporarily disconnected their infusion sets from their pumps, interrupting basal insulin infusion for 30 minutes, or on a separate day, only changed their infusion sets. Glucose levels were monitored for an additional 4 hours on both occasions. Changing infusion sets did not affect short-term glucose control. However, the 30-minute interruption of basal insulin infusion resulted in significant glucose elevations; approximately 1 mg/dL for each minute basal insulin infusion was interrupted.