Coffee consumption is associated with higher plasma adiponectin concentrations in women with and without type 2 diabetes: a prospective cohort study
- Catherine J. Williams, MPH1,
- Jessica L. Fargnoli1,
- Janice J. Hwang, MD1,
- Rob M. van Dam, PhD2,,4,
- George L. Blackburn, MD PhD5,
- Frank B. Hu, MD PhD2,,3,,4 and
- Christos S. Mantzoros, MD (cmantzor{at}bidmc.harvard.edu)1
- 1Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
- 2Department of Nutrition, Harvard School of Public Health, Boston, MA
- 3Department of Epidemiology, Harvard School of Public Health, Boston, MA
- 4Channing Laboratory, Brigham and Women's Hospital, Boston, MA
- 5Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA
Abstract
Abstract To test whether the beneficial effects of coffee consumption in metabolism might be explained by changes in circulating levels of adiponectin, we evaluated self-reported habitual coffee and tea consumption and caffeine intake as predictors of plasma adiponectin concentrations among 982 diabetic and 1058 non-diabetic women without cardiovascular disease from the Nurses' Health Study. Women with and without diabetes who drank ≥4 cups of coffee per day had significantly higher adiponectin concentrations than those who didn't drink coffee regularly (7.7μg/ml vs. 6.1μg/ml, P=0.004; 15.0μg/ml vs. 13.2μg/ml in non-diabetics, P=0.04). Similar associations were observed for caffeine intake. We confirm previously reported inverse associations of coffee consumption with inflammatory markers, C-reactive protein and TNF-α receptor II. Adjustment for adiponectin did not weaken these associations, nor did adjustment for inflammatory markers attenuate the association between coffee consumption and adiponectin. High consumption of caffeine-containing coffee is associated with higher adiponectin and lower inflammatory marker concentrations.
Footnotes
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- Received October 8, 2007.
- Accepted December 4, 2007.
- Copyright © American Diabetes Association
