Is a failure to recognize an increase in food intake a key to understanding insulin-induced weight gain?
- Miriam Ryan, PhD1,,2,
- M. Barbara E Livingstone, PhD2,
- Pierre-Henri Ducluzeau, MD PhD1,
- Agnès Sallé, MD PhD1,
- Manon Genaitay, BSc1 and
- Patrick Ritz, MD PhD (patrick.ritz{at}wanadoo.fr)1
- 1Department of Diabetes and Nutrition, CHU Angers F-49033, France
- 2University of Ulster, Coleraine, N.Ireland
Abstract
Abstract The present study aimed to assess the contribution of energy intake (EI) to positive energy balance and weight gain with insulin therapy. Changes in EI (self-report, weighed food intake), dietary behaviour (auto-questionnaires), resting energy expenditure (REE, indirect calorimetry), physical activity (accelerometry) and glucosuria were monitored over the first 6 months of insulin therapy in 46 diabetic adults. No change in REE, activity or glucosuria could explain weight gain in the type-1 (4.1±0.6kg, p<0.0001) or type-2 (1.8±0.8kg, p=0.02) diabetic groups. An increase in EI provides the most likely explanation for weight gain with insulin. However it is not being recognized because of significant under-estimation of self-reported food intake, which appears associated with increased dietary restraint.
Footnotes
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- Received June 20, 2007.
- Accepted December 11, 2007.
- Copyright © American Diabetes Association
