Effect of Lifestyle Intervention on the Occurrence of Metabolic Syndrome and its Components in the Finnish Diabetes Prevention Study

  1. Pirjo Ilanne-Parikka, MD (pirjo.ilanneparikka{at}diabetes.fi)1,,2,
  2. Johan G. Eriksson, MD, PhD3,,4,
  3. Jaana Lindström, PhD3,
  4. Markku Peltonen, PhD3,
  5. Sirkka Aunola, PhD5,
  6. Helena Hämäläinen, MD, PhD6,
  7. Sirkka Keinänen-Kiukaanniemi, MD, PhD7,,8,,9,
  8. Mauri Laakso, MD7,,8,,10,
  9. Timo T. Valle, MD3,
  10. Jorma Lahtela, MD, PhD11,
  11. Matti Uusitupa, MD, PhD12 and
  12. Jaakko Tuomilehto, MD, PhD on behalf of the Finnish Diabetes Prevention Study Group3,,4
  1. 1 Finnish Diabetes Association, The Diabetes Center, Tampere, Finland
  2. 2 Pirkanmaa Hospital District, Department of Research Administration, Tampere, Finland
  3. 3 National Public Health Institute, Department of Health Promotion and Chronic Disease Prevention, Diabetes Unit, Helsinki, Finland
  4. 4 University of Helsinki, Department of Public Health, Helsinki, Finland
  5. 5 National Public Health Institute, Department of Health and Functional Capacity, Laboratory for Population Research, Turku, Finland
  6. 6 Social Insurance Institution, Research Department, Turku, Finland
  7. 7 University of Oulu, Department of Public Health Science and General Practice, Oulu, Finland
  8. 8 Oulu Deaconess Institute, Department of Sport Medicine, Oulu, Finland
  9. 9 Oulu Health Centre, Oulu, Finland
  10. 10 Oulu University Hospital, Unit of General Practice, Oulu, Finland
  11. 11 Tampere University Hospital, Department of Internal Medicine, Tampere, Finland
  12. 12 University of Kuopio, Department of Public Health and Clinical Nutrition, Kuopio, Finland

    Abstract

    Objective: The aim of this secondary analysis of the Finnish Diabetes Prevention Study (DPS) was to assess the effects of a lifestyle intervention on metabolic syndrome and its components.

    Research Design and Methods: 522 middle-aged overweight men and women with impaired glucose tolerance were randomized into an individualized lifestyle intervention group or into a standard care control group in the DPS. The National Cholesterol Education Program criteria were used for the definition of the metabolic syndrome.

    Results: At the end of the study with a mean follow-up of 3.9 years we found a significant reduction in the prevalence of metabolic syndrome in the intervention group compared to the control group (OR of 0.62; 95% CI 0.40–0.95) as well in the prevalence of abdominal obesity (OR 0.48; 95% CI 0.28–0.81).

    Conclusions: The results suggest that lifestyle intervention may also reduce risk of cardiovascular diseases in long run.

    Conclusions: ClinicalTrials.gov ID: NCT00518167

    Footnotes

      • Received August 15, 2007.
      • Accepted December 24, 2007.

    This Article

    1. Published online before print January 9, 2008, doi: 10.2337/dc07-1117
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