Tracking and prediction of arterial blood pressure from childhood to young adulthood in 868 patients with type 1 diabetes: A multi-center, longitudinal survey in Germany and Austria
- Ina Knerr, MD, PhD (ina.knerr{at}uk-erlangen.de)1,
- Axel Dost, MD, PhD2,
- Rudolf Lepler, MD3,
- Klemens Raile, MD, PhD4,
- Edith Schober, MD, professor5,
- Wolfgang Rascher, MD, professor1 and
- Reinhard W. Holl, MD on behalf of the DPV Scientific Initiative Germany and Austria, professor6
- 1Children's and Adolescents' Hospital, University of Erlangen-Nuremberg, Germany
- 2University Children's Hospital, Jena, Germany
- 3Children's Hospital Wilhelmstift, Hamburg, Germany
- 4University Children's Hospital, Berlin, Germany
- 5University Children's Hospital, Vienna, Austria
- 6Division of Applied Information Technology, University of Ulm, Germany
Abstract
Objective: Arterial blood pressure (BP) was followed in 868 patients with type 1 diabetes from 6.0 to 19.9 yrs of age in 95 centers in Germany and Austria.
Research Design and Methods: European BP reference data for 28,043 children and adolescents were used with respect to age and gender. Data were stratified in the 3 groups pre-pubertal, pubertal and post-pubertal.
Results: Up to 4% of the participants in the younger age groups and 13.9% of the post-pubertal patients exhibited BP values >97th centile. BP levels correlated to hemoglobin A1c and BMI z score. Tracking of BP revealed that children with elevated BP had higher BP in adolescence and young adulthood.
Conclusions: Patients with higher BP in childhood showed elevated BP later in life. We need to focus on the diagnosis of hypertension in children with type 1 diabetes, and to study the efficacy of early intervention.
Footnotes
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- Received July 19, 2008.
- Accepted December 24, 2008.
- Copyright © American Diabetes Association
