Ethnic Differences in the Relationship between Adiponectin and Insulin Sensitivity in South Asian and Caucasian Women
- Marlene Martin, B.A.1,
- Latha P. Palaniappan, M.D., M.S.2,
- Andrea C. Kwan, B.A.3,
- Gerald M. Reaven, M.D. (greaven{at}cvmed.stanford.edu)4 and
- Peter D. Reaven, M.D.5
- 1 Stanford University School of Medicine, Stanford, CA
- 2 Palo Alto Medical Foundation Research Institute, Department of Health Care and Policy Research, Palo Alto, CA
- 3 University of California, San Diego, CA
- 4 Falk CVRC, Div. of Cardiovascular Medicine, Stanford University, Stanford, CA
- 5 Carl T. Hayden Veterans Affairs Medical Center, Dept. of Medicine, Phoenix, AZ
Abstract
Objective: To assess whether lower adiponectin concentrations in South Asian (SA) Indians may be responsible for their greater degree of insulin resistance.
Research Design and Methods: Insulin-mediated glucose uptake and plasma total and HMW adiponectin concentrations were quantified in 52 women of SA and Caucasian (CAU) ancestry and compared.
Results: Mean (± SD) total (2965 ± 1278 vs. 4235 ± 160) and HMW (1001 ± 352 vs. 1591 ± 854) adiponectin (ng/mL) were lower (p<0.005) in SA. CAU-IR had lower (p<0.01) total (2665 ± 1040 vs. 5133 ± 1086) and HMW (987±479 vs.1935 ±838) adiponectin than CAU-IS, but there were no significant differences between IR and IS SA. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS.
Conclusions: Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.
Footnotes
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- Received September 10, 2007.
- Accepted January 4, 2008.
- Copyright © American Diabetes Association
