A prospective study of passive smoking and risk of diabetes in a cohort of workers: the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) Study
- Yasuaki Hayashino, MD (hayasino-y{at}umin.net)1,
- Shunichi Fukuhara, MD1,
- Tomonori Okamura, MD2,
- Hiroshi Yamato, MD3,
- Hideo Tanaka, MD4,
- Taichiro Tanaka, MD5,
- Takashi Kadowaki, MD2 and
- Hirotsugu Ueshima, MD for the HIPOP-OHP Research Group2
- 1Kyoto University Graduate School of Medicine, Japan
- 2Shiga University of Medical Science, Japan
- 3University of Occupational and Environmental Health, Japan
- 4Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
- 5University of Yamanashi, Japan
Abstract
OBJECTIVE: We investigated the impact of active smoking and exposure to passive smoke on the risk of developing diabetes.
RESEARCH DESIGN AND METHODS: Data were analyzed from a cohort of participants in the High-risk and Population Strategy for Occupational Health Promotion Study (HIPOP-OHP) conducted in Japan from 1999 to 2004. Active and passive smoking status in the workplace was evaluated at baseline.
RESULTS: Of 6,498 participants (20.9% women), a total of 229 diabetes cases were reported over a median 3.4 years of follow-up. In the workplace, compared with zero exposure subjects, the multivariable-adjusted hazard ratios of developing diabetes were 1.81 (95%CI, 1.06–3.08: p=0.028) for present passive subjects and 1.99 (95%CI, 1.29–3.04: p=0.002) for present active smokers.
CONCLUSIONS: In this cohort, exposure to passive smoke in the workplace was associated with an increased risk of diabetes after adjustment for a large number of possible confounders.
Footnotes
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- Received September 30, 2007.
- Accepted January 19, 2008.
- Copyright © American Diabetes Association
