C-REACTIVE PROTEIN IN RELATION TO THE DEVELOPMENT OF MICROALBUMINURIA IN TYPE 1 DIABETES: THE OXFORD REGIONAL PROSPECTIVE STUDY
- M. Loredana Marcovecchio, MD1,,2,
- Cosimo Giannini, MD2,
- Barry Widmer, BSc1,
- R. Neil Dalton, PhD3,
- Stefano Martinotti, MD4,
- Francesco Chiarelli, MD2 and
- David B. Dunger, MD (dbd25{at}cam.ac.uk)1
- 1University Department of Paediatrics, Cambridge, UK
- 2University Department of Paediatrics and
- 4Department of Pathology, Chieti, Italy
- 3WellChild Laboratory, Evelina Children's Hospital, London, UK
Abstract
Objectives: To perform a longitudinal evaluation of high-sensitivity C-reactive protein (hs-CRP) in young people with type 1 diabetes (T1D) in relation to the development of microalbuminuria (MA).
Research Design and Methods: Hs-CRP was measured in 329 blood samples collected from 49 subjects with T1D with MA and 49 normoalbuminuric subjects matched for age, gender and duration of diabetes.
Results: In subjects developing MA a progressive rise in hs-CRP was detected with levels significantly higher in the years after the onset of MA when compared with levels before MA onset (p=0.003, age-adjusted p=0.06). After the onset of MA, hs-CRP levels were significantly higher in subjects with MA when compared with normoalbuminuric subjects (1.9[0.2–9.8] vs 1.1[0.2–6.4]mg/L; p=0.02; adjusted p=0.036).
Conclusions: In this population of young subjects with T1D, there was a significant increase in hs-CRP levels after the onset of MA, probably reflecting a general state of inflammation.
Footnotes
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- Received November 1, 2007.
- Accepted January 20, 2008.
- Copyright © American Diabetes Association
