Markedly blunted metabolic effects of fructose in healthy young females compared to males
- Caroline Couchepin, MD,
- Kim-Anne Lê, MSc,
- Murielle Bortolotti, MSc,
- Joana Amarante da Encarnaçao, BSc,
- Jean-Baptiste Oboni, BSc,
- Christel Tran, MD,
- Philippe Schneiter, PhD and
- Luc Tappy, MD (luc.tappy{at}unil.ch)
Abstract
Objective: to compare the metabolic effects of fructose in healthy males and females
Research Design And Methods: Fasting metabolic profile and hepatic insulin sensitivity were assessed by means of a hyperglycemic clamp in 16 healthy young males and female subjects after a 6-day fructose overfeeding
Results: Fructose overfeeding increased fasting triglyceride concentrations by 71% in males vs 16% in females (p<0.05). Endogenous glucose production was increased by 12%, alanin aminotransferase concentration was increased by 38%, and fasting insulin concentrations was increased by 14% after fructose overfeeding in males (all p<0.05), but were not significantly altered in females. Fasting plasma free fatty acids and lipid oxidation were inhibited by fructose in males, but not in females
Conclusions: Short term fructose overfeeding produces hypertriglyceridemia and hepatic insulin resistance in males, but these effects are markedly blunted in healthy young females.
Footnotes
-
- Received October 16, 2007.
- Accepted March 4, 2008.
- Copyright © American Diabetes Association
