Adipose Tissue Lipolysis is Upregulated in Lean and Obese Men During Acute Resistance Exercise

  1. Athanasios Chatzinikolaou, MSc1,
  2. Ioannis Fatouros, PhD1,
  3. Anatoli Petridou, PhD2,
  4. Athanasios Jamourtas, PhD3,
  5. Alexandra Avloniti, PhD1,
  6. Ioannis Douroudos, MSc1,
  7. Georgios Mastorakos, MD4,
  8. Christina Lazaropoulou, BSc5,
  9. Ioannis Papassotiriou, PhD5,
  10. Symeon Tournis, MD6,
  11. Asimina Mitrakou, MD4 and
  12. Vassilis Mougios, PhD (mougios{at}phed.auth.gr)2
  1. 1Physical Education and Sports Science, University of Thrace, Greece
  2. 2Physical Education and Sport Science, University of Thessaloniki, Greece
  3. 3Physical Education and Sports Science, University of Thessaly, Greece
  4. 4Endocrine Unit, Second Department of Obstetrics and Gynecology, Athens University Medical School, Greece
  5. 5Clinical Biochemistry, Aghia Sophia Hospital, Athens, Greece
  6. 6Garofalidis Laboratory for Musculoskeletal System Research, Athens University, Greece

    Abstract

    Objective To investigate the effect of acute resistance exercise on adipose tissue triacylglycerol lipase activity (TGLA) in lean and obese men.

    Research Design and Methods Nine lean and 8 obese men performed 30 min of circuit resistance exercise. Adipose tissue and blood were sampled during exercise for TGLA, metabolite, and hormone determinations. Respiratory exchange ratio (RER) was measured throughout exercise.

    Results Energy expenditure of exercise relative to body mass was higher in lean; RER was higher in obese suggesting lower fat oxidation. TGLA increased 18-fold at 5 min of exercise in lean and 16-fold at 10 min in obese. The delayed lipolytic activation in obese was reflected in serum non-esterified fatty acid and glycerol concentrations. Plasma insulin increased in obese but did not change in lean.

    Conclusions Resistance exercise upregulated adipose tissue lipolysis and enhanced energy expenditure in lean and obese men, with a delayed lipolytic activation in the obese.

    Footnotes

      • Received January 11, 2008.
      • Accepted March 25, 2008.

    This Article

    1. Published online before print March 28, 2008, doi: 10.2337/dc08-0072
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