Long-term follow-up of OGTT-derived glucose tolerance, insulin secretion and insulin sensitivity indices in subjects with glucokinase mutations (MODY2)
- Delphine Martin, MD1,
- Christine Bellanné-Chantelot, PhD2,
- Inge Deschamps, MD1,
- Philippe Froguel, MD, PhD3,
- Jean-Jacques Robert, MD, PhD1 and
- Gilberto Velho, MD, PhD (velho{at}bichat.inserm.fr)4
- 1AP-HP Hôpital Necker - Enfants Malades, Department of Pediatric Diabetology, Paris, France
- 2AP-HP Groupe Hospitalier Pitié-Salpétrière, Department of Genetics, Paris, France
- 3CNRS, UMR 8090, Institute of Biology, Pasteur Institute, Lille, France
- 4INSERM, Unité 695, Paris, France
Abstract
Objective We investigated the natural history of MODY2, notably the factors associated with deterioration of hyperglycemia over time.
Research Design And Methods We report an 11-year follow-up of glucose tolerance and of indices of insulin secretion and insulin sensitivity derived from oral glucose tolerance tests in 33 MODY2 subjects.
Results The variation between tests of glucose tolerance (expressed as the area under the glucose curve) was 6.9±3.2% (m±SEM), but individual results ranged from −20% to 61%. Deterioration of glucose tolerance between tests was associated with decreased insulin sensitivity, while insulin secretion remained stable.
Conclusions Glucose tolerance can remain stable over many years in subjects with MODY2, due to the relative stability of the glucokinase-related beta-cell defect. However, the development of insulin resistance may have an important role in the deterioration of the glucose tolerance and in the long-term evolution of the disorder.
Footnotes
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- Received October 18, 2007.
- Accepted April 4, 2008.
- Copyright © American Diabetes Association
