Association of 1,5-Anhydroglucitol and 2-Hour Postprandial Blood Glucose in Type 2 Diabetic Patients
- Christoph Stettler, MD (christoph.stettler{at}insel.ch)1,,2,
- Matthias Stahl, MD3,
- Sabin Allemann, PhD1,,2,
- Peter Diem, MD1,
- Kurt Schmidlin, DMD2,
- Marcel Zwahlen, PhD2,
- Walter Riesen, PhD4,
- Ulrich Keller, MD5 and
- Emanuel Christ, MD1
- 1Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Bern, Switzerland
- 2Institute of Social and Preventive Medicine, University of Bern, Switzerland
- 3Department of Internal Medicine, Cantonal Hospital, Olten, Switzerland
- 4Institute of Clinical Chemistry, Kantonsspital, St. Gallen, Switzerland
- 5Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital, Basel, Switzerland
Abstract
Objective To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-hour postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.
Research Design and Methods In 55 patients, self-measured postprandial blood glucose values were correlated with 1,5-AG values over pre-specified preceding time periods (3 days, 1 week, weekly up to 12 weeks).
Results The correlation coefficients were −0.34 (p<0.05) for postprandial glucose values in the preceding three days, −0.38 (p<0.001) for values during the week before a visit, and −0.40 (p<0.001) for the values obtained two weeks preceding the measurement of 1,5-AG. Correlations declined for time periods of ≥ 2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time-dependency of the correlation of HbA1c and fasting or postprandial glucose.
Conclusions 1,5-AG best reflected the 2-hour postprandial glucose values of the two previous weeks.
Footnotes
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- Received February 22, 2008.
- Accepted April 16, 2008.
- Copyright © American Diabetes Association
