Lifetime Risk of Cardiovascular Disease Among Individuals with and without Diabetes Stratified by Obesity Status in The Framingham Heart Study
- Caroline S. Fox, MD MPH (foxca{at}nhlbi.nih.gov),
- Michael J. Pencina, PhD,
- Peter W. F. Wilson, MD,
- Nina P. Paynter, PhD,
- Ramachandran S. Vasan, MD and
- Ralph B. D'Agostino, Sr, PhD
- 1From NHLBI's Framingham Heart Study, Framingham MA (CSF, MJP, NP, RSV, RBD), National Heart, Lung, and Blood Institute (CSF), Bethesda MD; the Division of Endocrinology, Metabolism, and Hypertension, Brigham and Women's Hospital and Harvard Medical School (CSF), Boston University Department of Mathematics (MJP, NP, RBD), Boston University School of Medicine (RSV); Department of Medicine, Emory University School of Medicine, Atlanta, Georgia (PWFW)
Abstract
Objective: We assessed the lifetime risk of CVD among individuals with and without obesity and diabetes.
Research Design and Methods: Participants were drawn from the Original and Offspring Cohorts of the Framingham Heart Study. Lifetime (30 year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years.
Results: Over 30 years, the lifetime risk of CVD among women with diabetes was 54.8% among normal weight women, but 78.8% among obese women. Among normal weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men.
Conclusion: The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.
Footnotes
-
- Received January 11, 2008.
- Accepted May 1, 2008.
- Copyright © American Diabetes Association
