Short-term Hyperglycemic Dysregulation in Patients with Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
- Sebastiaan Hammer, MSc (S.Hammer{at}LUMC.nl)1,,2,
- Jacqueline T. Jonker, MD1,,2,
- Hildo J. Lamb, MD, PhD2,
- Rutger W. van der Meer, MD2,
- W. Zondag, MD1,
- Jan M. Sepers, MD PhD3,
- Albert de Roos, MD PhD2,
- Johannes W.A. Smit, MD PhD1 and
- Johannes A. Romijn, MD PhD1
- Departments of 1Endocrinology and
- 2Radiology, Leiden University Medical Center
- Department of 3Internal Medicine, Medical Centre Alkmaar
Abstract
Objective: To evaluate the effects of hyperglycemia due to partial insulin deprivation on myocardial triglyceride (TG) content and myocardial function in patients with type 1 diabetes.
Research Design and Methods: Myocardial TG content and left ventricular (LV) function were measured by magnetic resonance (MR) spectroscopy and MR imaging during optimal glucoregulation and after 24 hours of partial insulin deprivation (n=10).
Results: Mean insulin infusion rate was 45 ± 5 units at baseline, whereas it was 27 ± 5 units during hyperglycemia (per 24 hours, P < 0.001). Plasma glucose levels increased from 8.4 ± 0.6 to 15.9 ± 0.8 mmol/l (P < 0.001), and plasma levels of non-esterified fatty acids from 0.31 ± 0.05 to 0.46 ± 0.07 mmol/l (P = 0.015). Hyperglycemia had no effects on myocardial TG content and LV function.
Conclusions: Short-term hyperglycemic dysregulation does not modulate myocardial TG content or myocardial function, despite considerable metabolic adaptations.
Footnotes
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- Received March 12, 2008.
- Accepted April 30, 2008.
- Copyright © American Diabetes Association
