Dysglycemia and a history of reproductive risk factors
- Sarah D. McDonald, MD, MSc (mcdonals{at}mcmaster.ca)1,
- Salim Yusuf, MD, DPhil2,,3,,4,
- Patrick Sheridan, MSc4,
- Sonia S. Anand, MD, PhD2,,4 and
- Hertzel C. Gerstein, MD, MSc2,,4,,5
- 1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
- 2Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
- 3Division of Cardiology
- 4Population Health Research Institute
- 5Division of Endocrinology and Metabolism
Abstract
Objective To identify reproductive risk factors associated with dysglycemia (diabetes, impaired glucose tolerance, and impaired fasting glucose) in a contemporary, multiethnic population.
Research Design and Methods Study Design We studied 14,661 women screened with an OGTT for the DREAM Trial. Reproductive risk factors were compared in normoglycemic and dysglycemic women.
Results Dysglycemia was significantly associated with the number of children born (OR 1.03 per child, 95% CI 1.01-1.05), age (OR 1.05 per year, 1.04-1.05), non-European ancestry (OR 1.09, 1.01-1.17), pre-eclampsia/eclampsia (OR 1.14, 1.02-1.27), irregular periods (OR 1.21, 1.07-1.36), and GDM (OR 1.53, 1.35-1.74). The relationship between GDM and dysglycemia did not differ across BMI tertiles (p=0.84), nor did the relationships of other risk factors.
Conclusions Reproductive factors, particularly GDM, are associated with dysglycemia in middle-aged women from many ethnicities. Reproductive factors can be used to counsel young women about their future risk of dysglycemia, while in middle age they may help screen for dysglycemia.
Footnotes
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- Received March 27, 2008.
- Accepted April 27, 2008.
- Copyright © American Diabetes Association
