Oxidation, Type 2 Diabetes and Coronary Heart Disease, a Complex Interaction. Findings from a Population-based Study

doi:10.2337/dc08-0558

Oxidation, Type 2 Diabetes and Coronary Heart Disease, a Complex Interaction. Findings from a Population-based Study

Saverio Stranges, MD, PhD (S.Stranges{at}warwick.ac.uk)^1,,²,
Joan M Dorn, PhD²,
Richard P Donahue, PhD²,
Richard W Browne, PhD³,
Jo L Freudenheim, PhD²,
Kathleen M Hovey, MSc² and
Maurizio Trevisan, MD, MSc²

¹Cardiovascular Medicine & Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, UK
²Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, New York, USA
³Department of Biotechnical and Clinical Laboratory Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, New York, USA

Abstract

Objective: We analyzed the interrelationship among oxidation, myocardial infarction (MI) and type 2 diabetes in a population-based case-control study of MI.

Research Design and Methods: Participants were 1,709 individuals from Western NY; 257 women and men with incident MI and 1,452 healthy controls (age 35-70 years). Lipid peroxidation was measured by plasma levels of thiobarbituric acid reactive substances (TBARS). History of type 2 diabetes was self report of medical diagnosis.

Results: In multivariate analyses, there was no significant difference in TBARS levels between cases and controls in both sexes. In sub-group analyses by diabetes status, diabetics, regardless of MI status, exhibited significantly higher TBARS values than non diabetics. In diabetic women: cases=1.84(nmol/ml), controls=1.83 (nmol/ml); in non diabetic women: cases=1.29(nmol/ml), controls=1.31(nmol/ml). In diabetic men: cases=1.65(nmol/ml), controls=1.97(nmol/ml); in non diabetic men: cases=1.36(nmol/ml), controls=1.36(nmol/ml).

Conclusions: While type 2 diabetes may be an important correlate of lipid peroxidation, clinical coronary heart disease may not.