Oxidation, Type 2 Diabetes and Coronary Heart Disease, a Complex Interaction. Findings from a Population-based Study
- Saverio Stranges, MD, PhD (S.Stranges{at}warwick.ac.uk)1,,2,
- Joan M Dorn, PhD2,
- Richard P Donahue, PhD2,
- Richard W Browne, PhD3,
- Jo L Freudenheim, PhD2,
- Kathleen M Hovey, MSc2 and
- Maurizio Trevisan, MD, MSc2
- 1Cardiovascular Medicine & Epidemiology Group, Clinical Sciences Research Institute, University of Warwick Medical School, Coventry, UK
- 2Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, New York, USA
- 3Department of Biotechnical and Clinical Laboratory Sciences, School of Medicine and Biomedical Sciences, University at Buffalo, New York, USA
Abstract
Objective: We analyzed the interrelationship among oxidation, myocardial infarction (MI) and type 2 diabetes in a population-based case-control study of MI.
Research Design and Methods: Participants were 1,709 individuals from Western NY; 257 women and men with incident MI and 1,452 healthy controls (age 35-70 years). Lipid peroxidation was measured by plasma levels of thiobarbituric acid reactive substances (TBARS). History of type 2 diabetes was self report of medical diagnosis.
Results: In multivariate analyses, there was no significant difference in TBARS levels between cases and controls in both sexes. In sub-group analyses by diabetes status, diabetics, regardless of MI status, exhibited significantly higher TBARS values than non diabetics. In diabetic women: cases=1.84(nmol/ml), controls=1.83 (nmol/ml); in non diabetic women: cases=1.29(nmol/ml), controls=1.31(nmol/ml). In diabetic men: cases=1.65(nmol/ml), controls=1.97(nmol/ml); in non diabetic men: cases=1.36(nmol/ml), controls=1.36(nmol/ml).
Conclusions: While type 2 diabetes may be an important correlate of lipid peroxidation, clinical coronary heart disease may not.
Footnotes
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- Received March 19, 2008.
- Accepted May 29, 2008.
- Copyright © American Diabetes Association
