The Association of C-Reactive Protein to Reduced Forced Vital Capacity in a Non-Smoking U.S. Population with Metabolic Syndrome and Diabetes

doi:10.2337/dc08-0801

The Association of C-Reactive Protein to Reduced Forced Vital Capacity in a Non-Smoking U.S. Population with Metabolic Syndrome and Diabetes

Hwa Mu Lee, MD (hwamuleemd{at}sbcglobal.net)¹,²,
Truc Vy Le, BS²,
Victor A. Lopez, BS² and
Nathan D. Wong, PhD²

¹Division of Pulmonary Medicine, Department of Medicine, University of California, Irvine, CA
²Heart Disease Prevention Program, Division of Cardiology, Department of Medicine, University of California, Irvine, CA

Abstract

Objective: The relationship of inflammation, measured by C-reactive protein (CRP), to forced vital capacity (FVC) in diabetes (DM) or metabolic syndrome (MetS) is not established. We investigated whether high CRP is related to reduced FVC in MetS and DM.

Research Design and Methods: We examined the association of MetS/DM and CRP (normal≤3mg/l, high>3mg/l) with predicted FVC in 4,272 non-smoking US adults aged 18-79 without lung disease in the Third National Health and Nutrition Examination Survey. Logistic regression examined odds of FVC<80% by CRP and MetS/DM.

Results: Mean FVC in persons with MetS/high CRP (95.7%) and DM/high CRP (93.7%) were lower than those with no MetS/DM/normal CRP (101.7%)(p<.01) and lower in MetS/high CRP (95.7%) compared to MetS/normal CRP (98.5%)(p<.01). Odds (95% confidence interval) of FVC<80% was highest in MetS/high CRP (4.26 [2.08-8.73], p<.01) when compared to no MetS/DM/normal CRP.

Conclusions: Elevated CRP is associated with lower FVC in persons with MetS.