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Normal glucose values are associated with a lower risk of mortality in hospitalized patients

  1. Alberto Bruno, MD (abruno{at}molinette.piemonte.it)1,
  2. Dario Gregori, PHD2,
  3. Antonio Caropreso, BD3,
  4. Fulvio Lazzarato, BS4,
  5. Michele Petrinco, BS2 and
  6. Eva Pagano, BS4
  1. 1Diabetologia ASO San Giovanni Battista of Turin
  2. 2Department of Public Health and Microbiology, University of Turin
  3. 3Central Laboratory ASO San Giovanni Battista of Turin
  4. 4Unit of cancer epidemiology - CPO Piemonte - University of Turin

    Abstract

    Objective- Hyperglycemia is a common condition in hospitalized patients. The aim of the study was to investigate the relationships between glycemia upon admission and mortality in a heterogeneous group of adult patients.

    Research Design and Methods- The three-year records released from a general hospital were associated to plasma glucose dataset of its general laboratory. A matched case control study was implemented (3338 cases-controls). All Patient Refined Diagnosis Related Groups and the Relative Risk of Death were the matching criteria. A multivariate conditional logistic regression model was used to evaluate the associations between death and glycemia.

    Results- Higher in-hospital mortality was associated with hyperglycemia or hypoglycemia while the lower risk was observed for values between 78 and 101 mg/dl.

    Conclusions- Our data confirm the relation between glycemia upon admission and mortality and suggest that slightly increased or decreased plasma glucose can be linked with increased mortality risks.

    Footnotes

      • Received April 11, 2008.
      • Accepted August 11, 2008.

    This Article

    1. Diabetes Care August 20, 2008
    1. All Versions of this Article:
      1. dc08-0672v1
      2. 31/11/2209 most recent
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