Zinc Intake and Biochemical Markers of Bone Turnover in Type 1 Diabetes
- Raelene E. Maser, PhD (rmaser{at}udel.edu)1,2,
- John N. Stabley, MS3,
- M. James Lenhard, MD2,
- Phyllis Owusu-Griffin, MD2,
- Michelle A. Provost-Craig, PhD3 and
- William B. Farquhar, PhD3
- 1Department of Medical Technology, University of Delaware, Newark, DE
- 2Diabetes and Metabolic Research Center, Christiana Care Health Services, Newark, DE
- 3Department of Health, Nutrition, and Exercise Sciences, University of Delaware, Newark, DE
Abstract
Objective To examine the relationship between zinc nutritive status and biochemical markers of bone turnover in type 1 diabetes.
Research design and methods Serum osteocalcin, urine N-telopeptides, and dietary intake data, obtained by 3-day food records, were assessed for 66 individuals with type 1 diabetes.
Results Zinc intake correlated with osteocalcin in the group overall (r=0.48, p<0.001) but not with N-telopeptides. Examined by gender, zinc and osteocalcin correlated for men (r=0.57, p<0.001), but did not reach statistical significance for women (r=0.34, p=0.09). A direct-entry linear regression model with osteocalcin as the dependent variable was performed. Duration, gender, HbA1c, insulin use/kg, total calorie intake and zinc intake were entered as potential independent variables. The model was statistically significant (R2=0.32, p<0.01). Zinc intake (p<0.001), however, was the only independent correlate of osteocalcin.
Conclusions This study provides evidence of a positive relationship between zinc intake and osteocalcin in type 1 diabetes.
Footnotes
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- Received June 12, 2008.
- Accepted September 2, 2008.
- Copyright © American Diabetes Association
