Differential effects of two different isoenergetic meals one rich in saturated and one rich in monounsaturated fat on endothelial function in subjects with type 2 diabetes mellitus
- Nicholas Tentolouris, MD (ntentol{at}med.uoa.gr)1,
- Christina Arapostathi, MD1,
- Despoina Perrea, PhD2,
- Despoina Kyriaki, MD1,
- Constantinos Revenas, MD1 and
- Nicholas Katsilambros, MD1
- 11st Department of Propaedeutic Medicine, Athens University Medical School, Athens, Greece
- 2Department of Experimental Surgery and Surgical Research, Athens University Medical School, Athens, Greece
Abstract
Objective- This cross-over study examined the acute effects of consumption of monounsaturated (MUFA) and saturated fatty acids (SAFA) on endothelial function in subjects with type 2 diabetes (T2DM).
Research design and methods- A total of 33 participants were examined after consumption of two different isocaloric meals, one rich in MUFA and one rich in SAFA in the form of extra virgin olive oil and butter, respectively. Endothelial function was assessed by determination of flow-mediated dilatation (FMD).
Results- FMD did not change significantly after the MUFA-rich meal but declined after the SAFA-rich meal. The FMD during the experiment, expressed as incremental area under the curve, increased after the MUFA-rich meal (+5.2 ± 2.5 %) and decreased after the SAFA-rich meal (-16.7 ± 6.0%) (Δ= -11.5 ± 6.4%, P=0.008).
Conclusions- Consumption of a SAFA-rich meal is harmful for the endothelium while a MUFA-rich meal does not impair endothelial function in subjects with T2DM.
Footnotes
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- Received May 19, 2008.
- Accepted September 2, 2008.
- Copyright © American Diabetes Association
