Is the new Mayo Clinic Quadratic (MCQ) equation useful for the estimation of glomerular filtration rate in type 2 diabetic patients?
- Néstor Fontseré, MD, PhD (34989nfb{at}comb.es),
- Jordi Bonal, MD, PhD,
- Isabel Salinas, MD, PhD,
- Manel Ramírez de Arellano, MD,
- Jose Rios,
- Ferran Torres, MD, PhD,
- Anna Sanmartí, MD, PhD and
- Ramón Romero, MD, PhD
Abstract
Objective: The aim of present study was to test the MCQ against isotopic GFR, compared with the MDRD and CG in DM2.
Research design and Methods: According to the values obtained with iothalamate, renal function of 118 DM2 patients was divided in hyperfiltration (26), normal (56) and CKD stages 3-4 (36). ANOVA, Bland-Altman and Lin's coefficient (Rc) to study accuracy.
Results: In hyperfiltration and normal function groups, all the prediction equations significantly underestimated the value obtained with isotopic GFR (P<0.05). In the CKD, all the equations also presented significant differences with the isotopic method. However, MDRD had a bias of -5.3 (Rc 0.452), CG -0.2 (Rc 0.471) and the MCQ -4.5 (Rc 0.526).
Conclusions: The MCQ and prediction equations proved inaccurate (excessive underestimation) in DM2 patients with hyperfiltration or normal renal function. In CKD, the results obtained provided no evidence of superiority of the MCQ over the MDRD or CG.
Footnotes
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- Received May 28, 2008.
- Accepted August 29, 2008.
- Copyright © American Diabetes Association
