Effect of a Successful Intensive Lifestyle Program on Insulin Sensitivity and Glucose Tolerance in Obese Youth
- Melissa Shaw, BS (melissa.m.shaw{at}yale.edu)1,
- Mary Savoye, RD, CDE2,
- Anna Cali, MD1,
- James Dziura, PhD2,
- William V. Tamborlane, MD1 and
- Sonia Caprio, MD1
- 1 Department of Pediatrics, Yale University, New Haven, CT
- 2Yale Center for Clinical Investigation, Yale University School of Medicine
Abstract
Objective: To evaluate the impact of a lifestyle program (Yale Bright Bodies Program) for obese children on glucose metabolism.
Research Design and Method: 13 Bright Bodies (BB) and 10 Clinic Care (CC) control subjects who were part of a large randomized clinical trial had 75 g oral glucose tolerance tests at the beginning and end of the 12 month study.
Results: BB subjects had significantly greater decreases in weight, BMI, and body fat than CC subjects and there changes in body composition were accompanied by marked improvements in insulin sensitivity (p=0.009) and glucose tolerance (p=0.04).
Conclusion: An intensive lifestyle program that successfully reduces body weight and body fat can markedly improve insulin sensitivity and glucose metabolism in obese youth.
Footnotes
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- Received May 12, 2008.
- Accepted September 26, 2008.
- Copyright © American Diabetes Association
